Resonant Frequency Hemostasis Analyzer
A method and device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state. The resonant frequency of the blood sample is determined before, during and after a hemostasis process. The changes in the resonant frequency of the blood sample are indicative of the hemostasis characteristics of the blood sample.
1 . An apparatus for measuring hemostasis comprising:
a container adapted to hold a blood sample, the container including a portion transparent to an emission from a sensor;
a shaker adapted to displace the container in order to cause a resonant excitation of the blood sample, the resonant excitation of the blood sample being time variant corresponding to coagulation and lysis of the blood sample; and
the sensor adapted to determine a movement of the blood sample corresponding to the resonant excitation of the blood sample within the container responsive to the displacement of the container by the shaker by generating the emission and directing the emission toward the blood sample through the portion;
wherein data from the sensor is indicative of the time variant resonant state of the blood sample.
2 . An apparatus according to claim 1 further comprising an analyzer coupled to the sensor to receive the data from the sensor, the analyzer being adapted to derive a hemostasis characteristic of the blood sample based upon the data from the sensor.
3 . An apparatus according to claim 1 , wherein the shaker displaces the container with a white noise frequency function.
4 . An apparatus according to claim 1 , wherein the shaker displaces the container at a displacement frequency and varies the displacement frequency responsive to changes in the resonant state of the blood sample.
5 . An apparatus according to claim 1 , wherein the container includes a self-sealing port for receiving the blood sample.
6 . An apparatus according to claim 1 , wherein the container is a sealed container.
7 . An apparatus according to claim 1 , wherein the container is safely disposable.
8 . An apparatus according to claim 1 , wherein the container comprises a first portion connected to a larger second portion, wherein the blood sample fills the first portion.
9 . An apparatus according to claim 1 wherein the sensor is an optical sensor.
10 . An apparatus according to claim 1 , wherein the sensor is an electric sensor.
11 . An apparatus according to claim 1 , wherein the sensor is an acoustic sensor.
12 . An apparatus for measuring hemostasis comprising:
a slot for receiving a container having therein a blood sample, wherein a portion of the container is transparent to an emission from a sensor;
a shaker adapted to displace the container in order to cause a resonant excitation of the blood sample, the resonant excitation of the blood sample being time variant corresponding to coagulation and lysis of the blood sample;
the sensor adapted to determine a movement of the blood sample within the container responsive to the displacement of the container by the shaker by generating the emission and directing the emission toward the blood sample through the portion; and
an analyzer coupled to the sensor to receive data from the sensor, the analyzer being adapted to derive a hemostasis characteristic of the blood sample based upon the data from the sensor;
wherein data from the sensor is indicative of the time variant resonant state of the blood sample.
13 . An apparatus according to claim 12 , wherein the shaker displaces the container with a white noise frequency function.
14 . An apparatus according to claim 12 , wherein the shaker displaces the container at a displacement frequency and varies the displacement frequency responsive to changes in the resonant frequency of the blood sample.
15 . An apparatus for measuring hemostasis comprising:
a container having a wall for enclosing a blood sample to be measured;
a shaker coupled to the container to excite the sample to resonant vibration through displacement of the container, the resonant state of the sample being time variant corresponding to hemostasis and lysis of the sample and the shaker adapted to excite the sample to resonant vibration in accordance with the time variant resonant state of the sample;
a sensor, the sensor having an emitter to emit an energy emission toward the sample and a detector to detect a change in the emission as a result interaction of the emission with the sample and to produce data indicative of the change in the emission, wherein the data is indicative of the time variant resonant vibration of the sample.
16 . An apparatus according to claim 15 , further comprising an analyzer coupled to the sensor to receive data in time from the sensor, the analyzer being adapted to derive a hemostasis characteristic of the blood sample based upon the data in time from the sensor.
17 . An apparatus according to claim 15 , wherein the shaker displaces the container with a white noise frequency.
18 . An apparatus according to claim 15 , wherein the shaker displaces the container at a displacement frequency and varies the displacement frequency responsive to changes in the resonant vibration of the blood sample.
19 . An apparatus according to claim 15 , wherein the container includes a self-sealing port for receiving the blood sample.
20 . An apparatus according to claim 15 , wherein the container is a sealed container.
21 . An apparatus according to claim 15 , wherein the container is safely disposable.
22 . An apparatus according to claim 15 , wherein the sensor is an optical sensor.
23 . An apparatus for measuring hemostasis comprising: a container adapted to hold a blood sample, the container including a portion transparent to an emission from a sensor; a shaker adapted to displace the container in order to cause an excitation of the blood sample, the blood sample being excited to a resonant state; and the sensor adapted to determine a movement of the blood sample within the container responsive to the displacement of the container by the shaker by generating the emission and directing the emission toward the blood sample through the portion; wherein data from the sensor is indicative of the resonant state of the blood sample.
24 . An apparatus according to claim 23 , further comprising an analyzer coupled to the sensor to receive the data from the sensor, the analyzer being adapted to derive a hemostasis characteristic of the blood sample based upon the data from the sensor.
25 . An apparatus according to claim 23 , wherein the shaker displaces the container with a frequency function having randomly selected frequency components selected from a range of frequencies.
26 . An apparatus according to claim 23 , wherein the shaker displaces the container at a displacement frequency and varies the displacement frequency responsive to changes in the resonant state of the blood sample.
27 . An apparatus according to claim 23 , wherein the container includes a self-sealing port for receiving the blood sample.
28 . An apparatus according to claim 23 , wherein the container is a sealed container.
29 . An apparatus according to claim 23 , wherein the container is safely disposable.
30 . An apparatus according to claim 23 , wherein the container comprises a first portion connected to a larger second portion, wherein the blood sample fills the first portion.
31 . An apparatus according to claim 23 , wherein the sensor is an optical sensor.
32 . An apparatus according to claim 23 , wherein the sensor is an electric sensor.
33 . An apparatus according to claim 23 wherein the sensor is an acoustic sensor.