Fumaric acid derivatives and ophthalmic lenses using the same
View Patent ↗Fumaric acid derivatives and ophthalmic lenses using them are disclosed. More specifically, a fumaric acid derivative having a hydrophilic group and a silicon-containing alkyl group within a molecule, and contact lenses or intraocular lenses using the same are disclosed. The fumaric acid derivatives of the present invention provide, on one hand, superior oxygen permeability by having a silicon-containing alkyl group within the molecular structure, and on the other hand, improved compatibility with other hydrophilic monomers by having a hydrophilic group within the same molecule. When ophthalmic lenses obtained by polymerizing monomer compositions containing the fumaric acid derivative are constructed as, for example, water content lenses, lenses with high oxygen permeability independent from the water content may be obtained, wherein the fumaric acid derivatives is superior in compatibility with the hydrophilic monomer used in combination and allows the combination in various mixing ratios.
1. A fumaric acid derivative having a hydrophilic group (R) and a silicon-containing alkyl group, which is represented by formula (1):
wherein Y 1 is O or NR 1 (R 1 is selected from the group consisting of hydrogen, C 1-3 alkyl and aryl);
R is selected from the group represented by the following formula:
Y 2 is selected from linear or branched C 3-10 alkylene, phenylene, cyclohexylene, —(CH 2 CH 2 O) o —CH 2 CH 2 CH 2 — (o is an integer from 1 to 10), or a group represented by any one of the following formulae:
X 1 , X 2 and X 3 are independently selected from the group consisting of methyl, trimethylsiloxy, and organosiloxy with 18 Si atoms or less.
2. An ophthalmic lens obtained by polymerizing a composition comprising the fumaric acid derivative of claim 1 .
3. The ophthalmic lens of claim 2 , formed from a copolymer polymerized from 10 to 80% by weight of the fumaric acid derivative and 90 to 20% by weight of another copolymerizable component.
4. The ophthalmic lens of claim 3 , wherein said another copolymerizable component is one or more polymerizable components selected from the group consisting of fumaric acid diesters other than the fumaric acid derivative, fumaric acid diamides, fumaric acid amide esters, N-vinyl lactams, N,N-dialkyl(meth)acrylamides, and hydroxyethyl (meth)acrylic acid esters.