Substituted N-aminomethylene sulfonamides, production and use thereof as medicaments

1. A compound of formula (I)

wherein:

R1 is hydrogen, halogen or —CF 3 ;

R2 is hydrogen, —NH 2 , —NH(C 1 -C 3 -alkyl), —N(C 1 -C 3 -alkyl) 2 or C 1 -C 3 -alkoxy and R1 and R2 may not simultaneously be hydrogen, wherein the alkyl and alkoxy moieties are unsubstituted;

R3 is unsubstituted or monosubstituted C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, aryl, heterocyclyl or heteroaryl,

where the substituents are selected from the group consisting of:

aryl, heteroaryl, heterocyclyl, aryl-(C 1 -C 6 -alkyl)-, heterocyclyl-(C 1 -C 6 -alkyl) -, heteroaryl-(C 1 -C 6 -alkyl)-, —O -aryl, fluorine, chlorine, bromine, —CF 3 , —OCF 3 , —NO 2 , —CN, —C(O)R7, hydroxy, C 1 -C 6 -alkyl and C 1 -C 3 -alkoxy,

and the aryl, heteroaryl and heterocyclyl fragments of these substituents may in turn be substituted by a substituent selected from the group consisting of fluorine, chlorine, bromine, oxo, —CF 3 , —OCF 3 , —NO 2 , —CN, hydroxy, C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy;

R4 and R5 are, independently of one another, hydrogen, unsubstituted or substituted C 1 -C 10 -alkyl or aryl-(C 1 -C 6 -alkyl)-,

where the substituents are selected from the group consisting of:

aryl, heteroaryl, heterocyclyl, aryl-(C 1 -C 6 -alkyl)-, heterocyclyl-(C 1 -C 6 -alkyl)-, heteroaryl-(C 1 -C 6 -alkyl)-, —O-aryl, fluorine, chlorine, bromine, —CF 3 , —OCF 3 , —NO 2 , —CN, —C(O)R7, hydroxy, C 1 -C 6 -alkyl and C 1 -C 3 -alkoxy,

and the aryl, heteroaryl and heterocyclyl fragments of these substituents may in turn be substituted by a substituent selected from the group consisting of fluorine, chlorine, bromine, oxo, —CF 3 , —OCF 3 , —NO 2 , —CN, hydroxy, C 1 -C 3 -alkyl or C 1 -C 3 -alkoxy; or

R4 and R5 form, together with the nitrogen atom to which they are bonded, an unsubstituted or substituted heterocyclyl,

where the substituents are selected from:

halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, phenyl, oxo, —NH 2 , —NH(C 1 -C 3 -alkyl), —N(C 1 -C 3 -alkyl) 2 , —OCF 3 , —CF 3 and hydroxy;

R6 is hydrogen, —SO 2 (C 1 -C 3 -alkyl), unsubstituted or substituted C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl or aryl-(C 1 -C 6 -alkyl)-,

where the substituents are selected from:

halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, phenyl, oxo, —NH 2 , —NH(C 1 -C 3 -alkyl), —N(C 1 -C 3 -alkyl) 2 , —OCF 3 , —CF 3 and hydroxy; or

R6 forms, together with R3 and X, if X is N, unsubstituted or substituted heterocyclyl,

where the substituents are selected from the group consisting of:

aryl, heteroaryl, heterocyclyl, aryl-(C 1 -C 6 -alkyl)-, heterocyclyl-(C 1 -C 6 -alkyl) -, heteroaryl-(C 1 -C 6 -alkyl)-, -O-aryl, fluorine, chlorine, bromine, -CF 3 , —OCF 3 , —NO 2 , —CN, —C(O)R7, hydroxy, C 1 -C 6 -alkyl and C 1 -C 3 -alkoxy,

and the aryl, heteroaryl and heterocyclyl fragments of these substituents may in turn be substituted by a substituent selected from the group consisting of fluorine, chlorine, bromine, oxo, —CF 3 , —OCF 3 , —NO 2 , —CN, hydroxy, C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy;

R7 is C 1 -C 3 -alkoxy, —O-phenyl, C 1 -C 3 -alkyl, —NH 2 , —NH(C 1 -C 3 -alkyl), —N(C 1 -C 3 -alky1) 2 or phenyl,

and the phenyl fragments of R7 may in turn be substituted by a substituent selected from the group consisting of fluorine, chlorine, bromine, —CF 3 , —OCF 3 , —NO 2 , —CN, hydroxy, C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy;

A is CO or CH 2 ;

X is NR6 or O; and

wherein

heteroaryl is a 5 to 10-membered, aromatic, mono-r bicyclic heterocycle which comprises one or more heteroatoms selected from N, O and S;

aryl is a 5 to 10-membered aromatic mono- or bicyclic system; and

heterocyclyl is a 5 to 10-membered, nonaromatic, mono- or bicyclic heterocycle which comprises one or more heteroatoms selected from N, O and S;

or a physiologically tolerated salt thereof;

with the proviso that when R2 is hydrogen and R1 is halogen, then —A—X—R3 is not i) —C(O) —O—CH 2 —CH 2 —NH 2 , ii) —C(O) —NH—CH 2 —CH═CH 2 , iii) —C(O) —NH—CH 2 —CH 2 —Z with Z equal to halogen, hydroxy, trialkylammonium, mesylate or tosylate, iv) —C(O) —O—(C 1 -C 6 -alkyl), v) —C(O) —NH-benzimidazolyl or vi) —C(O) —NH-(1,2,3,4-tetrahydroisoquinolinyl), where the —CH 2 —CH 2 - fragment in i) and iii) may be substituted by 1 to 4 alkyl radicals R 1 to R 4 each having 1 to 4 carbon atoms, where one of the radicals R 1 to R 4 may also be a carboxy, hydroxymethyl or an alkyloxycarbonyl group having not more than 5 carbon atoms or one or two of the radicals R 1 to R 4 may be isopropyl, isobutyl, tert-butyl, phenyl or cycloalkyl having 5 to 6 carbon atoms, and where the benzimidazolyl and the (1,2,3,4-tetrahydroisoquinolinyl) fragment in v) and vi) may be unsubstituted or at least monosubstituted.

2. The compound as claimed in claim 1 , wherein:

R1 is hydrogen, halogen or —CF 3 ;

R2 is hydrogen, —NH 2 , —NH(C 1 -C 3 -alkyl), —N(C 1 -C 3 -alkyl) 2 or C 1 -C 3 -alkoxy and R1 and R2 may not simultaneously be hydrogen, wherein the alkyl and alkoxy moieties are unsubstituted;

R3 is unsubstituted or substituted C 1 -C io -alkyl, C 2 -C 6 -alkenyl, aryl or heterocyclyl,

where the substituents are selected from the group consisting of:

aryl, aryl-(C 1 -C 6 -alkyl)-, fluorine, chlorine, bromine, —CF 3 , —C(O)O—(C 1 -C 3 -alkyl), —C(O)O-phenyl, hydroxy, C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy;

R4 and R5 are, independently of one another, hydrogen, unsubstituted or substituted C 1 -C 10 -alkyl,

where the substituents are selected from:

halogen, C 1 -C 6 -alkoxy, —CF 3 and hydroxyl; or

R4 and R5 form, together with the nitrogen atom to which they are bonded,

unsubstituted or substituted heterocyclyl,

where the substituents are selected from:

halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, —CF 3 and hydroxy;

R6 is hydrogen, —SO 2 (C 1 -C 3 -alkyl), unsubstituted or substituted C 1 -C 10 -alkyl or C 2 -C 6 -alkenyl,

where the substituents are selected from:

halogen, C 1 -C 6 -alkoxy and —CF 3 ; or

R6 forms, together with R3 and X, if X is equal to N, unsubstituted or substituted heterocyclyl,

where the substituents are selected from the group consisting of:

aryl, aryl-(C 1 -C 6 -alkyl)-, fluorine, chlorine, bromine, —CF 3 , —C (O)O—(C 1 -C 3 -alkyl), —C(O)O-phenyl, hydroxy, C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy,

and the aryl fragments of these substituents may in turn be substituted by fluorine, chlorine, bromine, oxo, —CF 3 , hydroxy, C 1 -C 3 -alkyl or C 1 -C 3 -alkoxy;

A is CO or CH 2 ;

X is NR6 or O;

aryl is phenyl, indanyl or naphthyl; and

heterocyclyl is morpholinyl, pyrrolidinyl, piperidinyl, tetrahydropyranyl, thiazolidinyl, dihydroisoxazolyl, piperazinyl or tetrahydrofuranyl;

or a physiologically acceptable salt thereof.

3. The compound as claimed in claim 1 , where:

R1 is chlorine or —CF 3 ;

R2 is hydrogen or —NH 2 ;

R3 is unsubstituted or substituted C 1 -C 6 -alkyl, C 2 -C 3 -alkenyl or phenyl,

where the substituents are selected from: C 1 -C 3 -alkyl, C 1 -C 3 -alkoxy, chlorine, fluorine and hydroxy;

R4 and R5 are each methyl;

R6 is hydrogen, —SO 2 CH 3 or C 1 -C 6 -alkyl;

A is CH 2 ; and

X is NR6 or O;

or a physiologically acceptable salt thereof.

4. A pharmaceutical composition comprising the compound as claimed in claim 1 , or a physiologically acceptable salt thereof and a physiologically acceptable carrier.

5. A method of inhibiting monoacylglyeride lipase or hormone-sensitive lipase comprising administering to a patient in need thereof an effective amount of the compound as claimed in claim 1 , or a physiologically acceptable salt thereof.

6. A method for treating non-insulin-dependent diabetes mellitus, diabetic syndrome or obesity which comprises administering to a patient in need thereof an effective amount of the compound as claimed in claim 1 , or a physiologically acceptable salt thereof.

7. The pharmaceutical composition as claimed in claim 4 , in the form of a pill, tablet, coated tablet, suckable tablet, granules, capsule, hard or soft gelatin capsule, aqueous solutions, alcoholic solution, oily solution, syrup, emulsion, suspension, pastille, solution for injection or infusion, ointment, tincture, cream, lotion, dusting powder, spray, transdermal therapeutic system, nasal spray, aerosol, aerosol mixture, microcapsule, implant, rod or patch.

8. A process for preparing the compound of formula (I) as claimed in claim 1 , which comprises:

reacting a compound of formula (II) in a solvent with R4R5NCH(OCH 3 ) 2 .

9. A process for preparing the compound of formula (I) as claimed in claim 1 , which comprises:

reacting a compound of formula (III), wherein A—Z is selected from COC1, CH 2 C1 and CH 2 Br, with HX-R3 in an inert solvent.

10. A pharmaceutical composition comprising the compound as claimed in claim 2 , or a physiologically acceptable salt thereof and a physiologically acceptable carrier.

11. A pharmaceutical composition comprising the compound as claimed in claim 3 , or a physiologically acceptable salt thereof and a physiologically acceptable carrier.

12. The compound according to claim 1 , which is:

4-Chloro-3-(dimethylaminomethylenesulfamoyl)—N-(3 ,3 ,5 -trimethylcyclohexyl)benzamide;

4-Chloro-3-(dimethylaminomethylenesulfamoyl)—N-(2,2,6,6-tetramethylpiperidin-4-y1)benzamide;

4-Chloro-3-(dimethylaminomethylenesulfamoyl)-N-(3,5-dimethylphenyl)benzamide;

4-Chloro-3-(dimethylaminomethylenesulfamoyl)benzoic acid (cis-2,6-dimethyl-morpholide);

4-Chloro-3-(dimethylaminomethylenesulfamoyl)benzoic acid (3,3-dimethyl-piperidide);

4-Chloro-3-(dimethylaminomethylenesulfamoyl)—N-(2,2-dimethylpropyl)benzamide;

4-Chloro-3-(dimethylaminomethylenesulfamoyl)—N-(2-chlorophenylmethyl)benzamide; or 4-Chloro-3-(N-methylpiperazinomethylenesulfamoyl)—N-(3,3,5-dimethylcyclohexyl)benzamide;

or a physiologically acceptable salt thereof.

13. A pharmaceutical composition comprising the compound as claimed in claim 12 , or a physiologically acceptable salt thereof and a physiologically acceptable carrier.

14. A method of inhibiting monoacylglyeride lipase or hormone-sensitive lipase comprising administering to a patient in need thereof an effective amount of the compound as claimed in claim 2 , or a physiologically acceptable salt thereof.

15. A method of inhibiting monoacylglyeride lipase or hormone- sensitive lipase comprising administering to a patient in need thereof an effective amount of the compound as claimed in claim 3 , or a physiologically acceptable salt thereof.

16. A method of inhibiting monoacylglyeride lipase or hormone- sensitive lipase comprising administering to a patient in need thereof an effective amount of the compound as claimed in claim 12 , or a physiologically acceptable salt thereof.