IP Library Granted Patent US 7,741,359
Granted Patent B2
US 7,741,359 · App. 11/779,849 · Granted Jun 22, 2010

Hydrogen sulfide derivatives of non-steroidal anti-inflammatory drugs

Assignee: Antibe Therapeutics Inc.
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Quick Facts
Patent No.
US 7,741,359
App. No.
11/779,849
Granted
Jun 22, 2010
Kind
B2
Abstract

The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H 2 S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.

Claims (17)

1. A compound of the formula:

B—C(O)O—X  (Formula II)

wherein B—C(O)O— is derived from an NSAID having a free carboxyl group, wherein the NSAID is selected from the group consisting of acetylsalicylic acid, diclofenac, indomethacin, lumiracoxib, naproxen, ibuprofen, ketoprofen and flurbiprofen;

and X is

or a salt thereof.

2. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

3. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

4. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

5. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

6. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

7. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE ADD THE SECOND ASSIGNOR PREVIOUSLY RECORDED AT REEL: 061315 FRAME: 0428. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Nov 29, 2022
From: 2831094 ONTARIO INC.; ANTIBE HOLDINGS INC.
To: ANTIBE AMALCO INC.
Reel/Frame 062015/0794 →
MERGER Recorded Aug 25, 2022
From: 2831094 ONTARIO INC.
To: ANTIBE AMALCO INC.
Reel/Frame 061315/0428 →
MERGER Recorded Aug 25, 2022
From: ANTIBE AMALCO INC.; ANTIBE THERAPEUTICS INC.
To: ANTIBE THERAPEUTICS INC.
Reel/Frame 061315/0501 →
CHANGE OF NAME Recorded Nov 5, 2013
From: ANTIBE THERAPEUTICS INC.
To: ANTIBE HOLDINGS INC.
Reel/Frame 031580/0142 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2007
From: WALLACE, JOHN L.; CIRINO, GIUSEPPE; SANTAGADA, VINCENZO; CALIENDO, GIUSEPPE
To: ANTIBE THERAPEUTICS INC.
Reel/Frame 019811/0169 →
Continuity (4)
Continuation In Part PCTCA200600048400 · Mar 31, 2006
Provisional Application 6088718800 · Jan 30, 2007
Provisional Application 6080763900 · Jul 18, 2006
Related Publication 20080004245A1 · Jan 3, 2008