Biodegradable polymer for marking tissue and sealing tracts
A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.
1. An implant for insertion into a lumen or void during a surgical procedure comprising:
a polymer plug and
a sealant covering at least a portion of the polymer plug, wherein the sealant comprises a hydrogel and anchors the implant against migration after insertion into the lumen or void.
2. The implant of claim 1 , wherein the sealant ensleeves the polymer plug.
3. The implant of claim 1 , wherein the sealant completely encapsulates the polymer plug.
4. The implant of claim 1 , wherein the sealant expands when contacted by water.
5. The implant of claim 1 , wherein the hydrogel comprises a biodegradable monomer selected from the group consisting of glycolide, lactide, c-caprolactone, p-dioxanone, trimethylene carbonate, and mixtures thereof.
6. The implant of claim 1 , wherein the hydrogel comprises a non-biodegradable polymer selected from the group consisting of poly(hydroxyalkyl methylacrylates), poly(acrylamide), poly(methacrylamide), poly(N-vinyl-2-pyrrolidone), anionic hydrogels, cationic hydrogels, poly(vinyl alcohol), poly(ethylene glycol) and its derivatives, and mixtures thereof.
7. The implant of claim 1 , wherein the polymer plug has a cylindrical cross section.
8. The implant of claim 1 , wherein the polymer plug has an annular cross section.
9. The implant of claim 1 , wherein the polymer plug comprises poly(lactide), poly(glycolide), poly(caprolactone), poly(dioxanone), poly(ethylene glycol), collagen, gelatin, copolymers of the foregoing, and mixtures of the foregoing.