IP Library › Patent Application 11790124
Patent Application
App. No. 11/790,124

Composite endoluminal prostheses for treating vulnerable plaque

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Quick Facts
Patent No.
US None
App. No.
11/790,124
Abstract

The invention provides expandable tubular endoluminal prostheses for the treatment of atherosclerotic lesions, such as vulnerable plaques, and methods for treating such lesions using the prostheses. The endoprostheses may include at least two expandable ring-like elements disposed on the inside or about the outer surface of an at least substantially tubular biodegradable element. The ring-like elements may be radio-opaque and may have a sinuate form. In use, a prosthesis according to the invention is expanded in a blood vessel so that the tubular biodegradable element at least partially covers an atherosclerotic lesion, such as a vulnerable plaque.

Claims (78)

1 . An expandable endovascular prosthesis, comprising:

at least two expandable annular elements, each having a central axis; and

an at least substantially tubular biodegradable element having an inner surface, an outer surface and a longitudinal central axis,

wherein the central axis of each of the expandable annular elements and of the tubular biodegradable element are at least substantially aligned.

2 . The prosthesis of claim 1 , wherein

the expandable annular elements are at least substantially sinuate in form.

3 . The prosthesis of claim 1 , wherein

at least two of the expandable annular elements are disposed within the tubular biodegradable element.

4 . The prosthesis of claim 1 , wherein

at least two of the expandable annular elements are disposed about the outer surface of the tubular biodegradable element.

5 . The prosthesis of claim 1 , wherein

the at least two expandable annular elements are affixed to the tubular biodegradable element.

6 . The prosthesis of claim 1 , wherein

at least one of the expandable annular elements is at least partially radio-opaque.

7 . The prosthesis of claim 1 , wherein

at least one of the expandable annular elements is at least partially metallic.

8 . The prosthesis of claim 1 , wherein

the prosthesis is at least partially balloon expandable.

9 . The prosthesis of claim 1 , wherein

the at least two expandable annular elements are a least partially self-expanding.

10 . The prosthesis of claim 1 , wherein

of the at least two expandable annular elements, one is disposed at or near one end of the tubular biodegradable element and another is disposed at or near the opposite end of the tubular biodegradable element.

11 . The prosthesis of claim 1 , wherein

the tubular biodegradable element is at least partially porous.

12 . The prosthesis of claim 1 , wherein

the tubular biodegradable element has pores having diameters at least predominantly less than 500 microns.

13 . The prosthesis of claim 1 , wherein

the tubular biodegradable element has pores having diameters at least predominantly in the range of 20 to 200 microns.

14 . The prosthesis of claim 1 , wherein

the expandable annular elements are at least substantially non-biodegradable.

15 . The prosthesis of claim 1 , wherein

the expandable annular elements are biodegradable at a slower rate than the tubular biodegradable element.

16 . The prosthesis of claim 1 , wherein

at least some of the expandable annular elements consists essentially of non-biodegradable metallic material.

17 . The method of claim 16 , wherein

the tubular biodegradable element is at least substantially polymeric.

18 . The prosthesis of claim 1 , wherein

neighboring annular elements are not connected to each other by connective elements.

19 . The prosthesis of claim 1 , wherein

at least two neighboring annular elements are connected by at least one connective element.

20 . The prosthesis of claim 1 , wherein neighboring annular elements are connected by at least one connective element.

21 . A method for treating vulnerable plaque in a patient in need thereof, comprising the steps of:

deploying a prosthesis according to claim 1 at a site of a vulnerable plaque in blood vessel of a patient.

22 . The method of 21 , further comprising the step of delivering the prosthesis to the site using a delivery catheter.

23 . The method of claim 21 , further comprising the step of:

prior to deploying the endoprosthesis, locating the site of the vulnerable plaque.

24 . The method of claim 21 , wherein

at least two of the expandable annular elements of the prosthesis are disposed within the tubular biodegradable element.

25 . The method of claim 21 , wherein

at least two of the expandable annular elements of the prosthesis are disposed about the outer surface of the tubular biodegradable element.

26 . The method of claim 21 , wherein

the at least two expandable annular elements of the prosthesis are affixed to the tubular biodegradable element.

27 . The method of claim 21 , wherein

at least one of the expandable annular elements of the prosthesis is at least partially radio-opaque.

28 . The method of claim 21 , wherein

at least one of the expandable annular elements of the prosthesis is at least partially metallic.

29 . The method of claim 21 , wherein

the prosthesis is at least partially balloon expandable.

30 . The method of claim 21 , wherein

the at least two expandable annular elements of the prosthesis are a least partially self-expanding.

31 . The method of claim 21 , wherein

of the at least two expandable annular elements of the prosthesis, one is disposed at or near one end of the tubular biodegradable element and another is disposed at or near the opposite end of the tubular biodegradable element.

32 . The method of claim 21 , wherein

the tubular biodegradable element of the prosthesis is at least partially porous.

33 . The method of claim 21 , wherein

the tubular biodegradable element of the prosthesis has pores having diameters at least predominantly less than 500 microns.

34 . The method of claim 21 , wherein

the tubular biodegradable of the prosthesis has pores having diameters at least predominantly in the range of 20 to 200 microns.

35 . An expandable endovascular prosthesis, comprising:

at least two expandable non-biodegradable metallic annular elements, each having a central axis; and

an at least substantially tubular biodegradable polymeric element having a wall and a longitudinal central axis, wherein the wall is porous forming pores at least predominantly 500 microns or less in diameter,

wherein the central axis of each of the expandable annular elements and of the tubular biodegradable element are at least substantially aligned.

36 . The prosthesis of claim 35 , wherein

neighboring annular elements are not connected to each other by connective elements.

37 . The prosthesis of claim 35 , wherein

at least two neighboring annular elements are connected by at least one connective element.

38 . The prosthesis of claim 37 , wherein

neighboring annular elements are connected by at least one connective element.

Assignments (2)
SECURITY AGREEMENT Recorded Apr 27, 2009
From: SPENCER TRASK INVESTMENT PARTNERS LLC
To: COLLATERAL AGENTS, LLC
Reel/Frame 022614/0926 →
SECURITY INTEREST Recorded Apr 25, 2008
From: PRESCIENT MEDICAL, INC.
To: SPENCER TRASK INVESTMENT PARTNERS LLC
Reel/Frame 020875/0415 →