Chemical compound and its use
The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.
1. A compound of the formula (I)
in which R represents cyclopentyl or isopropyl, or a salt thereof.
2. A compound of the formula (Ia)
or a salt thereof.
3. A compound of the formula (Ib)
or a salt thereof.
4. A pharmaceutical composition comprising the compound of the formula (I) as defined in any of claims 1 to 3 in combination with an inert nontoxic pharmaceutically suitable auxiliary.
5. A pharmaceutical composition comprising the compound of the formula (I) as defined in any of claims 1 to 3 in combination with one or more further active compounds selected from the group consisting of antidiabetics, platelet aggregation inhibitors, anticoagulants, calcium antagonists, angiotensin AII antagonists, ACE inhibitors, beta blockers, phosphodiesterase inhibitors, stimulators of soluble guanylate cyclase, cGMP enhancers, diuretics, thyroid receptor agonists, HMG-CoA reductase inhibitors, squalene synthase inhibitors, squalene epoxidase inhibitors, oxidosqualene cyclase inhibitors, ACAT inhibitors, MTP inhibitors, PPAR agonists, fibrates, lipase inhibitors, cholesterol absorption inhibitors, bile acid reabsorption inhibitors, polymeric bile acid adsorbers and lipoprotein(a) antagonists.
6. A process for preparing the compound of the formula (Ia) as defined in claim 2 , characterized in that the compound of the formula (IIa)
is initially, by asymmetric reduction, converted into the compound of the formula (IIIa)
which is then either
[A] by introduction of a hydroxyl protective group reacted to give a compound of the formula (IVa)
in which
PG represents a hydroxyl protective group,
and then, by diastereoselective reduction, converted into a compound of the formula (Va)
in which PG is as defined above,
or
[B] initially reduced diastereoselectively to give the compound of the formula (VIa)
which is then, by regioselective introduction of the hydroxyl protective group PG, converted into a compound of the formula (Va),
the compound of the formula (Va) is then, using a fluorinating agent, reacted to give a compound of the formula (VIIa)
in which PG is as defined above,
and the hydroxyl protective group PG is then cleaved off giving the compound of the formula (Ia)
and the compound of the formula (Ia) is optionally converted into a salt thereof.
7. A process for preparing the compound of the formula (Ib) as defined in claim 3 , characterized in that the compound of the formula (IIb)
is initially, by asymmetric reduction, converted into the compound of the formula (IIIb)
which is then either
[A] by introduction of a hydroxyl protective group reacted to give a compound of the formula (IVb)
in which
PG represents a hydroxyl protective group,
and then, by diastereoselective reduction, converted into a compound of the formula (Vb)
in which PG is as defined above,
or
[B] initially reduced diastereoselectively to give the compound of the formula (VIb)
which is then, by regioselective introduction of the hydroxyl protective group PG, converted into a compound of the formula (Vb),
the compound of the formula (Vb) is then, using a fluorinating agent, reacted to give a compound of the formula (VIIb)
in which PG is as defined above,
and the hydroxyl protective group PG is then cleaved off giving the compound of the formula (Ib)
and the compound of the formula (Ib) is optionally converted into a salt thereof.
8. The process of claim 6 , wherein PG is a radical of the formula —SiR 1 R 2 R 3 , in which R 1 , R 2 and R 3 are identical or different and represent (C 1 -C 4 ) alkyl.
9. The process of claim 7 , wherein PG is a radical of the formula —SiR 1 R 2 R 3 , in which R 1 , R 2 and R 3 are identical or different and represent (C 1 -C 4 ) alkyl.