Compositions and methods for studying and treating inflammatory diseases and disorders
Disclosed are compositions and methods that can be used in the treatment of diseases and disorders caused, exacerbated or otherwise affected by inflammation.
1. A composition comprising a viral vector, wherein delivery of the vector to a cell inhibits a mediator of inflammation, wherein the vector comprises a lentivirus, wherein the lentivirus is a feline immuno deficiency virus (FIV), wherein the vector comprises a nucleic acid operably linked to an expression control sequence and wherein the nucleic acid inhibits expression of the mediator of inflammation, wherein the nucleic acid is an siRNA, wherein the siRNA inhibits gene expression of COX-2, and wherein the siRNA comprises the nucleic acid sequence SEQ ID NO:53.
2. A composition comprising a cell, wherein the cell comprises the vector of claim 1 .