IP Library Granted Patent US 7,449,884
Granted Patent B1
US 7,449,884 · App. 11/800,419 · Granted Nov 11, 2008

Enhanced spectral selectivity for steady-state free precession imaging

Assignee: The Board of Trustees of the Leland Stanford Junior University
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Quick Facts
Patent No.
US 7,449,884
App. No.
11/800,419
Granted
Nov 11, 2008
Kind
B1
Abstract

A method of collecting image data with selective spectral suppression for at least two species is provided. A sequence of RF excitation pulses is repeatedly applied, whereby a repeated sequence of at least two substantially different spectrally selective steady-state magnetizations is established. Magnetic gradients are applied between said RF pulses. A plurality of magnetic resonance image (MRI) signals is acquired. The plurality of MRI signals is combined using a weighted combination where the weights depend on a control parameter that adjusts a trade-off between selective spectral suppression and signal-to-noise ratio (SNR).

Claims (252)

1. A method of providing selective spectral suppression in steady-state free procession (SSFP) magnetic resonance imaging, comprising:

a) acquiring a plurality of SSFP images with different RF phase increments of an object to be imaged; and

b) combining the plurality of SSFP images using a weighted combination in which the weights depend on a control parameter that adjusts a trade-off between selective spectral suppression and signal-to-noise ratio (SNR).

2. The method, as recited in claim 1 , wherein the combining the plurality of SSFP images uses a weighted combination of complex-valued SSFP images in which the weighting is based on the SSFP images themselves and which a power of the weight is a function of the control parameter.

3. The method, as recited in claim 1 , wherein the combining of the plurality of SSFP images uses a weighting according to the equations

Y

1

=

D

0

-

0

p

D

0

-

0

+

i

D

0

-

180

p

D

0

-

180

1

1

+

p

Y

2

=

D

0

-

0

p

D

0

-

0

-

i

D

0

-

180

p

D

0

-

180

1

1

+

p

wherein Y 1 is an image for a first species and Y 2 is an image for a second species, D 0-0 is a data set of consecutive RF pulses that are all in phase and D 0-180 is a data set of consecutive RF pulses that are all out of phase and p is a real number in the range (−1, 0), where p is a control parameter.

4. The method, as recited in claim 3 , further comprising displaying the combined plurality of SSFP images.

5. The method, as recited in claim 4 , wherein the first species is water and the second species is fat.

6. The method, as recited in claim 5 , further comprising repeatedly applying a sequence of RF excitation pulses with a phase progression which provides an SSFP image in which a spectrally dependent steady-state magnetization is established.

7. The method, as recited in claim 6 , further comprising applying magnetic gradients between said RF excitation pulses.

8. The method, as recited in claim 1 , further comprising displaying the combined plurality of SSFP images.

9. The method, as recited in claim 8 , further comprising repeatedly applying a sequence of RF excitation pulses with a phase progression which provides an SSFP image in which a spectrally dependent steady-state magnetization is established.

10. The method, as recited in claim 9 , further comprising applying magnetic gradients between said RF excitation pulses.

11. The method, as recited in claim 1 , wherein the combining the plurality of SSFP images uses a weighted combination of complex-valued SSFP images in which the weighting is based on the SSFP images themselves and which a power of the weight is a function of the control parameter and further comprising displaying the combined plurality of SSFP images.

12. The method, as recited in claim 11 , further comprising repeatedly applying a sequence of RF excitation pulses with a phase progression, which provides an SSFP image in which a spectrally dependent steady-state magnetization is established.

13. The method, as recited in claim 12 , further comprising applying magnetic gradients between said RF excitation pulses.

14. A method, comprising:

a) repeatedly applying a sequence of RF excitation pulses with a phase progression, which provides an SSFP image in which a spectrally dependent steady-state magnetization is established;

b) applying magnetic gradients between said RF excitation pulses;

c) acquiring a plurality of suppression in steady-state free procession SSFP images with different RF phase increments of an object to be imaged; and

d) combining the plurality of SSFP images using a weighted combination using a weighting according to the equations

Y

1

=

D

0

-

0

p

D

0

-

0

+

i

D

0

-

180

p

D

0

-

180

1

1

+

p

Y

2

=

D

0

-

0

p

D

0

-

0

-

i

D

0

-

180

p

D

0

-

180

1

1

+

p

wherein Y 1 is an image for a first species and Y 2 is an image for a second species, D 0-0 data set based on consecutive RF pulses that are all in phase and D 0-180 is a data set based on consecutive RF pulses that are all out of phase and p is a real number in the range (−1, 0), where p is a control parameter;

e) displaying the combined plurality of SSFP images.

15. The method, as recited in claim 14 , wherein the first species is water and the second species is fat.

16. An apparatus, comprising:

a magnet system;

a controller electrically connected to the magnet system, comprising:

a display;

at least one processor; and

computer readable media, comprising:

computer readable code for acquiring a plurality of SSFP images with different RF phase increments of an object to be imaged; and

computer readable code for combining the plurality of SSFP images using a weighted combination in which the weights depend on a control parameter that adjusts a trade-off between selective spectral suppression and signal-to-noise ratio (SNR).

17. The apparatus, as recited in claim 16 , wherein the computer readable code for combining the plurality of SSFP images uses a weighted combination of complex-valued SSFP images in which the weighting is based on the SSFP images themselves and which a power of the weight is a function of the control parameter p.

18. The apparatus, as recited in claim 16 , wherein the computer readable code for combining of the plurality of SSFP images uses a weighting according to the equations

Y

1

=

D

0

-

0

p

D

0

-

0

+

i

D

0

-

180

p

D

0

-

180

1

1

+

p

Y

2

=

D

0

-

0

p

D

0

-

0

-

i

D

0

-

180

p

D

0

-

180

1

1

+

p

wherein Y 1 is an image for a first species and Y 2 is an image for a second species, D 0-0 is a data set of consecutive RF pulses that are all in phase and D 0-180 is a data set of consecutive RF pulses that are all out of phase and p is a real number in the range (−1, 0), where p is a control parameter.

19. The apparatus, as recited in claim 18 , further comprising computer readable code for displaying the combined plurality of SSFP images.

Assignments (3)
CONFIRMATORY LICENSE Recorded Jun 24, 2013
From: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 030675/0257 →
CONFIRMATORY LICENSE Recorded Nov 23, 2008
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 021879/0508 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 1, 2007
From: CUKUR, TOLGA; NISHIMURA, DWIGHT G.
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 019633/0517 →