Modulating toll-like receptor activity
View Patent ↗This description provides methods and materials related to modulating Toll-like receptor activity. For example, methods and materials for increasing or decreasing the responsiveness of a TLR4 polypeptide are provided.
1. A method for decreasing Toll-like receptor-4 activation in cells, wherein said cells are in the presence of a Toll-like receptor-4 agonist selected from LPS and heparin sulfate, and wherein said cells are in a mammal with inflammation symptoms as a result of an inflammatory condition, said method comprising:
administering an SDF-1 polypeptide to said cells under conditions wherein the level of said Toll-like receptor-4 activation in said cells is decreased thereby reducing the level of inflammation symptoms in said mammal, and
determining the severity of said symptoms after said administering.
2. The method of claim 1 , wherein said cells are leukocytes, endothelial cells, or parenchymal cells.
3. The method of claim 1 , wherein said Toll-like receptor-4 agonist is LPS.
4. The method of claim 1 , wherein said mammal is a human.