Therapeutic Agent for Sensory Abnormality
The present invention provides therapeutic agents for sensory disorders represented by the following formula (1): [wherein R 1 , R 2 , and R 3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group]. The cyclohexenone long chain alcohol of the present invention improves hyperalgesia or hypoalgesia, and thus is useful as therapeutic agents for sensory disorders. Sensory disorders that can be prevented or treated by the present invention include chronic intractable pain, neurogenic pain, reduction of pain threshold caused by nerve injuries, hypesthesia or hyperesthesia caused by diabetes and nerve injuries, and the like.
1 . A therapeutic and/or preventive agent for a sensory disorder, comprising, as an active ingredient, a cyclohexenone long chain alcohol compound represented by the following formula (1):
wherein R 1 , R 2 , and R 3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group.
2 . The therapeutic and/or preventive agent of claim 1 , wherein R 1 is a methyl group and X is a linear C10-C28 alkylene group.
3 . The therapeutic and/or preventive agent of claim 2 , wherein R 2 is a methyl group.
4 . The therapeutic and/or preventive agent of claim 2 , wherein R 3 is a methyl group.
5 . The therapeutic and/or preventive agent of claim 1 , wherein R 1 and R 2 are hydrogen atoms.
6 . The therapeutic and/or preventive agent of claim 1 , wherein the cyclohexenone long chain alcohol compound is selected from the group consisting of the following compounds:
3-(10-hydroxydecyl)-2-cyclohexen-1-one (3-(10-hydroxydecyl)-2-cyclohexenone);
3-(11-hydroxyundecyl)-2-cyclohexen-1-one (3-(11-hydroxyundecyl)-2-cyclohexenone);
3-(12-hydroxydodecyl)-2-cyclohexen-1-one (3-(12-hydroxydodecyl)-2-cyclohexenone);
3-(13-hydroxytridecyl)-2-cyclohexen-1-one (3-(13-hydroxytridecyl)-2-cyclohexenone);
3-(14-hydroxytetradecyl)-2-cyclohexen-1-one (3-(14-hydroxytetradecyl)-2-cyclohexenone);
3-(10-hydroxydecyl)-4-methyl-2-cyclohexen-1-one (3-(10-hydroxydecyl)-4-methyl-2-cyclohexenone);
3-(11-hydroxyundecyl)-4-methyl-2-cyclohexen-1-one (3-(11-hydroxyundecyl)-4-methyl-2-cyclohexenone);
3-(12-hydroxydodecyl)-4-methyl-2-cyclohexen-1-one (3-(12-hydroxydodecyl)-4-methyl-2-cyclohexenone);
3-(13-hydroxytridecyl)-4-methyl-2-cyclohexen-1-one (3-(13-hydroxytridecyl)-4-methyl-2-cyclohexenone);
3-(14-hydroxytetradecyl)-4-methyl-2-cyclohexen-1-one (3-(14-hydroxytetradecyl)-4-methyl-2-cyclohexenone);
4,4-dimethyl-3-(10-hydroxydecyl)-2-cyclohexen-1-one (4,4-dimethyl-3-(10-hydroxydecyl)-2-cyclohexenone);
3-(11-hydroxyundecyl)-4,4-dimethyl-2-cyclohexen-1-one (3-(11-hydroxyundecyl)-4,4-dimethyl-2-cyclohexenone);
3-(12-hydroxydodecyl)-4,4-dimethyl-2-cyclohexen-1-one (3-(12-hydroxydodecyl)-4,4-dimethyl-2-cyclohexenone);
3-(13-hydroxytridecyl)-4,4-dimethyl-2-cyclohexen-1-one (3-(13-hydroxytridecyl)-4,4-dimethyl-2-cyclohexenone);
3-(14-hydroxytetradecyl)-4,4-dimethyl-2-cyclohexen-1-one (3-(14-hydroxytetradecyl)-4,4-dimethyl-2-cyclohexenone);
3-(10-hydroxydecyl)-2-methyl-2-cyclohexen-1-one (3-(10-hydroxydecyl)-2-methyl-2-cyclohexenone);
3-(11-hydroxyundecyl)-2-methyl-2-cyclohexen-1-one (3-(11-hydroxyundecyl)-2-methyl-2-cyclohexenone);
3-(12-hydroxydodecyl)-2-methyl-2-cyclohexen-1-one (3-(12-hydroxydodecyl)-2-methyl-2-cyclohexenone);
3-(13-hydroxytridecyl)-2-methyl-2-cyclohexen-1-one (3-(13-hydroxytridecyl)-2-methyl-2-cyclohexenone);
3-(14-hydroxytetradecyl)-2-methyl-2-cyclohexen-1-one (3-(14-hydroxytetradecyl)-2-methyl-2-cyclohexenone);
3-(12-hydroxydodecyl)-2,4,4-trimethyl-2-cyclohexen-1-one (3-(12-hydroxydodecyl)-2,4,4-trimethyl-2-cyclohexenone);
3-(13-hydroxytridecyl)-2,4,4-trimethyl-2-cyclohexen-1-one (3-(13-hydroxytridecyl)-2,4,4-trimethyl-2-cyclohexenone);
3-(14-hydroxytetradecyl)-2,4,4-trimethyl-2-cyclohexen-1-one (3-(14-hydroxytetradecyl)-2,4,4-trimethyl-2-cyclohexenone);
3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one (3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexenone); and
3-(16-hydroxyhexadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one (3-(16-hydroxyhexadecyl)-2,4,4-trimethyl-2-cyclohexenone).
7 . The method of claim 16 , wherein the sensory disorder is chronic intractable pain.
8 . The method of claim 16 , wherein the sensory disorder is neurogenic pain.
9 . The method of claim 16 , wherein the sensory disorder is reduction of pain threshold caused by nerve injury.
10 . The method of claim 16 , wherein the sensory disorder is hypesthesia caused by nerve injury.
11 . The method of claim 16 , wherein the sensory disorder is hypesthesia or hyperesthesia caused by polyneuropathy.
12 . The method of claim 11 , wherein the polyneuropathy is hypesthesia or hyperesthesia caused by chronic polyneuropathy.
13 . The method of claim 16 , wherein the sensory disorder is hypesthesia or hyperesthesia caused by diabetes.
14 . The method of claim 16 , wherein the sensory disorder is mononeuropathy.
15 . The method of claim 14 , wherein the mononeuropathy is compression neuropathy.
16 . A method for either one, or both, of treating and preventing a sensory disorder comprising the step of administering a cyclohexenone long chain alcohol compound represented by the following formula (1):
wherein R 1 , R 2 , and R 3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group.
17 . The therapeutic and/or preventive agent of claim 3 , wherein R 3 is a methyl group.