Composition and methods for the enterosorption and management of toxins

1. An oral composition capable of binding an aflatoxin comprising:

an effective amount of an isolated calcium aluminosilicate clay having an particle size less than 80 microns has a detectable level of OCDD and is free from detectable levels of total tetra-dioxin, total penta-dioxin, and total hexa-dioxin;

wherein the detectable levels of total tetra-dioxin are above 0.024 pg/L;

the detectable levels of total penta-dioxin are above 0.025 pg/L; and the detectable levels of total hexa-dioxin are above 0.039 pg/L;

wherein the detectable level of OCDD is about 0.362 pg/L;

wherein an orally consumed effective amount of the isolated calcium aluminosilicate clay composition is useful for mitigating toxic effects of the aflatoxin in a living system at risk for aflatoxicosis.

2. The composition of claim 1 , wherein the isolated calcium aluminosilicate clay has a chemical composition comprising:

CaO above about 3.2%; MgO ranging from about 4.0 to about 5.4%; Fe 2 0 3 ranging from about 5.4 to about 6.5; K 2 0 ranging from about 0.50 to about 0.90%; Na 2 O ranging from about 0.10 to about 0.30%; MnO ranging from about 0.01 to about 0.03%; Al 2 0 3 ranging from about 14.8 to about 18.2%;

and SiO 2 ranging from about 62.4 to about 73.5%; wherein, the chemical composition is given as weight percent.

3. The composition of claim 1 , wherein the aflatoxins are selectively sorbed to the calcium aluminosilicate clay composition.

4. The composition of claim 1 , wherein the isolated calcium aluminosilicate clay composition exhibits a pH ranging from about 5 to about 9 in solution.

5. An oral composition for use as a preventive therapy to mitigate effects of environmental toxins in a living system, comprising:

an effective amount of an isolated calcium aluminosilicate clay having an average particle size less than 80 microns has a detectable level of OCDD and is free from detectable levels of total tetra-dioxin, total penta-dioxin, and total hexa-dioxin;

the isolated calcium aluminosilicate clay is capable of binding the environmental toxins;

wherein total tetra-dioxin have detectable levels above 0.024 pg/L; total penta-dioxin have detectable levels above 0.025 pg/L; and total hexa-dioxin have detectable levels above 0.039 pg/L;

wherein the detectable level of OCDD is about 0.362 pg/L;

wherein an orally consumed effective amount of the isolated calcium aluminosilicate clay composition is useful for mitigating effects of the environmental toxins in a living system at risk for environmental toxin exposure.

6. The composition of claim 5 , wherein the isolated calcium aluminosilicate clay has a chemical composition comprising:

CaO above about 3.2%; MgO ranging from about 4.0 to about 5.4%; Fe 2 0 3 ranging from about 5.4 to about 6.5; K 2 0 ranging from about 0.50 to about 0.90%; Na 2 O ranging from about 0.10 to about 0.30%; MnO ranging from about 0.01 to about 0.03%; Al 2 0 3 ranging from about 14.8 to about 18.2%;

and SiO 2 ranging from about 62.4 to about 73.5%; wherein, the chemical composition is given as weight percent.

7. The composition of claim 5 , wherein the aflatoxins are selectively sorbed to the calcium aluminosilicate clay composition.

8. The composition of claim 5 , wherein the isolated calcium aluminosilicate clay composition exhibits a pH ranging from about 5 to about 9 in solution.

9. A method of mitigating an effect of an environmental toxin in a system, comprising steps:

(a) administering orally an effective amount of an isolated calcium aluminosilicate clay having an average particle size less than 80 microns has a detectable level of OCDD about 0.362 pg/L and is free from detectable levels of total tetra-dioxin having a detectable levels above 0.024 pg/L; total penta-dioxin having detectable levels above 0.025 pg/L; and total hexa-dioxin having detectable levels above 0.039 pg/L;

(b) waiting a period of time; and

(c) repeating step (a)-(b) until the effects of the environmental toxin are mitigated.

10. The method of claim 9 , further comprising the step of: selecting the isolated calcium aluminosilicate clay to have a chemical composition comprising: CaO above 3.2%; MgO ranging from about 4.0 to about 5.4%; Fe 2 0 3 ranging from about 5.4 to about 6.5; K 2 0 ranging from about 0.50 to about 0.90%; Na 2 O ranging from about 0.10 to about 0.30%; MnO ranging from about 0.01 to about 0.03%; Al 2 0 3 ranging from about 14.8 to about 18.2%; and SiO 2 ranging from about 62.4 to about 73.5%; wherein, the chemical composition is given as weight percent.

11. The method of claim 9 , further comprising a step of: selecting the system to be one predisposed to cancer.

12. The method of claim 9 , further comprising a step of: selecting the period of time to be less than about 24 hours.

13. The method of claim 9 , further comprising a step of: selecting the isolated calcium aluminosilicate clay to have a pH ranging from about 5 to about 9.

14. A method of mitigating an exposure risk in a system for liver cancer and aflatoxicosis when the system is exposed to an environmental aflatoxin, the method comprising the steps:

(a) administering orally an effective amount of an isolated calcium clay having an average particle size less than 80 microns has a detectable level of OCDD about 0.362 pg/L and is free from detectable levels of total tetra-dioxin having detectable levels above 0.024 pg/L; total penta-dioxin having detectable levels above 0.025 pg/L; and total hexa-dioxin having detectable levels above 0.039 pg/L;

(b) waiting a period of time; and

(c) repeating step (a)-(b) until the system is free of exposure risk to aflatoxins.

15. The method of claim 14 , further comprising selecting the isolated calcium aluminosilicate clay to have a chemical composition comprising: CaO above 3.2%; MgO ranging from about 4.0 to about 5.4%; Fe 2 0 3 ranging from about 5.4 to about 6.5; K 2 0 ranging from about 0.50 to about 0.90%; Na 2 O ranging from about 0.10 to about 0.30%; MnO ranging from about 0.01 to about 0.03%; Al 2 0 3 ranging from about 14.8 to about 18.2%; and SiO 2 ranging from about 62.4 to about 73.5%; wherein, the chemical composition is given as weight percent.

16. The method of claim 14 , further comprising selecting the system to be one predisposed to liver cancer and aflatoxicosis.

17. The method of claim 14 , further comprising selecting the period of time to be less than about 24 hours.

18. The method of claim 14 , further comprising a step of: selecting the isolated calcium aluminosilicate clay to have a pH ranging from about 5 to about 9.

19. A method of treating a subject exposed to high levels of aflatoxin, or low levels of aflatoxin over an extended period of time, comprising:

(a) administering orally an effective amount of an isolated calcium aluminosilicate clay having an average particle size less than 80 microns has a detectable level of OCDD about 0.362 pg/L and is free from detectable levels of total tetra-dioxin having a detectable levels above 0.024 pg/L; total penta-dioxin having detectable levels above 0.025 pg/L; and total hexa-dioxin having detectable levels above 0.039 pg/L;

(b) waiting a period of time; and

(c) repeating step (a)-(b) until the subject's effects of exposure to aflatoxins are lessened or eliminated.

20. The method of claim 19 , further comprising selecting the isolated calcium aluminosilicate clay to have a chemical composition comprising: CaO above 3.2%; MgO ranging from about 4.0 to about 5.4%; Fe 2 0 3 ranging from about 5.4 to about 6.5; K 2 0 ranging from about 0.50 to about 0.90%; Na 2 O ranging from about 0.10 to about 0.30%; MnO ranging from about 0.01 to about 0.03%; Al 2 0 3 ranging from about 14.8 to about 18.2%; and SiO 2 ranging from about 62.4 to about 73.5%; wherein, the chemical composition is given as weight percent.

21. The method of claim 19 , further comprising selecting the system to be one predisposed to liver cancer and aflatoxicosis.

22. The method of claim 19 , further comprising selecting the period of time to be less than about 24 hours.

23. The method of claim 19 , further comprising a step of: selecting the isolated calcium aluminosilicate clay to have a pH ranging from about 5 to about 9.