Pyrrolidinone anilines as progesterone receptor modulators
The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a combination thereof, wherein R 1 , R 2 , and X are as defined herein. Compounds of the present invention are useful as progesterone receptor modulators.
1. A compound which is 2-chloro-4-{[(3S)-1-methyl-5-oxo-3-pyrrolidinyl][(2-methylphenyl)methyl]amino}benzonitrile.
2. A composition that comprises a) the compound of claim 1 ; and b) a pharmaceutically acceptable carrier.
3. A pharmaceutically acceptable salt of the compound of claim 1 .
4. A method comprising administering to a patient in need thereof an effective amount of the compound of claim 1 or a pharmaceutically-acceptable salt thereof to treat endometreosis, uterine fibroids, dysmenorrhea, menorrhagia, pre-term labor, or infertility.
5. A method comprising administering to a patient in need thereof an effective amount of the compound of claim 1 or a pharmaceutically-acceptable salt thereof to provide contraception or hormone therapy.