PHARMACEUTICAL COMPOSITION

1 . A water washable anhydrous pharmaceutical composition for the enhanced topical delivery of biologically active poorly water soluble compounds; said composition comprises of;

a) at least one biologically active compound in amounts between 0.01 and 20% by weight presented in dissolved state

b) a water miscible solvent or mixture of solvents as a solubilizer of a biologically active compound

c) a moisture absorbent, insoluble or poorly soluble in the said solvent

d) at least one physiologically acceptable water miscible or water dispersible surfactant in amounts between 0.5 and 60% by weight

2 . A composition of claim 1 wherein said biologically active compound is completely solubilized in said solvent and does not precipitate immediately on contact with skin or wet surface

3 . A composition of claim 1 wherein said moisture absorbent does not decrease solubility of biologically active hydrophobic compound in composition and does not cause its precipitation during storage

4 . A pharmaceutical composition as set forth in claim 1 , containing no triglycerides or hydrophobic esters

5 . A composition of claim 1 wherein said water miscible solvent is selected from a group of aliphatic alcohols, glycols, propylene glycol, butylene glycol, polyethylene glycols, ethoxydiglycol, isosorbide ethers, propylene carbonate, dimethylsulfoxide (DMSO), dimethylacetamide (DMA), dimethylformamide (DMFA), isopropylidene glycerin (Solketal®), glycerol formal, tetrafurol, dimethylisosorbide, ethyllactate, N-methylpyrrolidone (Pharmasolve®), pyrrolidone-2 (Soluphor®) or a mixture thereof

6 . A composition of claim 1 wherein said moisture absorbent is selected from a group of inorganic silicates, phosphates, carbonates, dried silicagels, colloidal, amorphous or granulated silicon dioxide, alumosilicates, zeolites, powdered molecular sieves; polysaccharides, powdered cellulose, cellulose fibers, cellulose lint or fabric; microcrystalline cellulose, starch and starch derivatives, alginic acid and salts thereof, cellulose gum, xanthan gum or acacia gum, crosslinked polyacrylates or polyvinylpyrrolidone, or a mixture thereof

7 . A composition as set forth in claim 1 wherein said surfactant is selected from a group of dermatologically acceptable polyethoxylated aliphatic or aromatic derivatives, polyglycerin derivatives, sugar and polyol esters or ethers anionic surfactants, cationic surfactants or a mixture thereof

8 . A composition of claim 1 wherein said moisture absorbent comprises of physiologically acceptable hydrophobic or amphiphilic compounds with melting point not less than 25° C., selected from a group of cetearyl or cetostearyl alcohol, polyethylene glycols, ethoxylated esters of aliphatic or aromatic alcohols or sterols, lecithin and phospholipids, alkyl esters of glycerol or alkyl esters of glycols, or a mixture thereof

9 . A composition of claim 1 wherein said water miscible solvent comprises of dimethylisosorbide, ethoxydiglycol or a mixture thereof in ratio from 1:10 to 10:1, preferably 1:3 to 3:1, in amounts between 10% and 90% of the composition by weight.

10 . A pharmaceutical composition as set forth in claim 1 , wherein said compound is selected from a group of non-steroidal antiinflammatory drugs (NSAIDs), steroids, hormones, liposoluble vitamins, prostaglandins, local anesthetics, analgesics, antivirals, antibacterials, antibiotics, antifungals, antimetabolites, cytostatics, antipsoriatics, retinoids, immune suppressors, antihistamines, tranquilizers, pyrethroids, antiparasitics, diindolylmethane, organic acids and benzoyl peroxide.

11 . A pharmaceutical composition as set forth in claim 1 , which may further contain pharmaceutically acceptable excipients, surfactants, antioxidants, preservatives, stabilizers, sorbents, solvents, rheology modifiers, colorants and fragrances.