Granted Patent
B2
US 10,287,311 · App. 11/854,218 · Granted May 14, 2019
Modified fluorinated nucleoside analogues
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Abstract
The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.
Claims (4)
1. A method for the treatment of hepatitis C infection, which comprises:
providing to a human subject in need thereof an antivirally effective amount of a (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleoside (β-D) or its pharmaceutically acceptable salt of the structure:
wherein R 1 and R 7 are independently H, a monophosphate, a diphosphate, or a triphosphate; and
R 4 is NH 2 or OH.
Assignments (7)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 22, 2022
From: GILEAD PHARMASSET LLC
To: GILEAD SCIENCES, INC.
Reel/Frame 059791/0730 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 17, 2018
From: CLARK, JEREMY L.
To: PHARMASSET, INC.
Reel/Frame 046371/0841 →
NUNC PRO TUNC ASSIGNMENT
Recorded Jul 17, 2018
From: CLARK, JEREMY L.
To: PHARMASSET, LTD.
Reel/Frame 046371/0882 →
CHANGE OF NAME
Recorded Mar 23, 2012
From: PHARMASSET, INC.
To: GILEAD PHARMASSET LLC
Reel/Frame 027921/0559 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 11, 2011
From: CLARK, JEREMY
To: PHARMASSET, LTD.
Reel/Frame 027214/0896 →
ARTICLES OF DOMESTICATION
Recorded Nov 11, 2011
From: PHARMASSET, LTD.
To: PHARMASSET, INC.
Reel/Frame 027215/0286 →
Cited By (2)