IP Library › Granted Patent US 12,458,656
Granted Patent B2
US 12,458,656 · App. 19/215,054 · Granted Nov 4, 2025

Advantageous anti-HCV combination therapy

Inventors: Jean-Pierre Sommadossi (Boston, MA); Adel Moussa (Burlington, MA); Keith M. Pietropaolo (Boxford, MA); Xiao-Jian Zhou (Arlington, MA)
Assignee: Atea Pharmaceuticals, Inc.
A61K31/7076A61K31/5365A61P31/16
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Quick Facts
Patent No.
US 12,458,656
App. No.
19/215,054
Granted
Nov 4, 2025
Kind
B2
Abstract

A synergistic pharmaceutical combination of Compound 1 or a pharmaceutically acceptable salt thereof (e.g., Compound 1-A) and Compound 2 or a pharmaceutically acceptable salt thereof, as well as its uses to treat hepatitis C or a condition related to hepatitis C, as well as methods for the manufacture of the pharmaceutical combination:

Claims (22)

1 . A method of treating HCV in a human in need thereof, comprising administering an effective amount of Compound 1, or a pharmaceutically acceptable salt thereof,

in a dosage form in combination with an effective amount of Compound 2, or a pharmaceutically acceptable salt thereof,

in a dosage form.

2 . The method of claim 1 , wherein Compound 1 is Compound 1-A

3 . The method of claim 1 , wherein Compound 1 or a pharmaceutically acceptable salt thereof and Compound 2 or a pharmaceutically acceptable salt thereof are in the same dosage form.

4 . The method of claim 1 , wherein Compound 1 or a pharmaceutically acceptable salt thereof and Compound 2 or a pharmaceutically acceptable salt thereof are in different dosage forms.

5 . The method of claim 1 , wherein the combination is administered orally.

6 . The method of claim 1 , wherein the combination is administered parenterally.

7 . The method of claim 1 , wherein from about 100 mg to about 800 mg of Compound 1, or an equivalent amount of a pharmaceutically acceptable salt thereof, is administered.

8 . The method of claim 7 , wherein about 550 mg of Compound 1, or an equivalent amount of a pharmaceutically acceptable salt thereof, is administered.

9 . The method of claim 2 , wherein about 600 mg of Compound 1-A, is administered.

10 . The method of claim 1 , wherein from about 90 to about 360 mg of Compound 2 or a pharmaceutically acceptable salt thereof is administered.

11 . The method of claim 10 , wherein about 180 mg of Compound 2 or a pharmaceutically acceptable salt is administered.

12 . The method of claim 1 , wherein Compound 1 or a pharmaceutically acceptable salt thereof and Compound 2 or a pharmaceutically acceptable salt thereof are in two dosage forms.

13 . The method of claim 2 , wherein about 300 mg of Compound 1-A is administered, wherein Compound 1-A and Compound 2 or a pharmaceutically acceptable salt thereof are in two dosage forms.

14 . The method of claim 12 , wherein about 90 mg of Compound 2 or a pharmaceutically acceptable salt is administered.

15 . The method of claim 1 , wherein the combination is administered once per day.

16 . The method of claim 1 , wherein the combination is administered twice per day.

17 . The method of claim 1 , wherein the combination is administered for up to 12 weeks.

18 . The method of claim 1 , wherein the combination is administered for up to 8 weeks.

19 . The method of claim 2 , wherein about 600 mg of Compound 1-A and about 180 mg of Compound 2 is administered.

20 . The method of claim 2 , wherein about 600 mg of Compound 1-A and about 180 mg of Compound 2 is administered in two dosage forms.

Continuity (4)
Continuation 18540608 · Dec 14, 2023
Continuation PCTUS2022034083 · Jun 17, 2022
Provisional Application 63212047 · Jun 17, 2021
Related Publication 20250281520A1 · Sep 11, 2025
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