Compounds and pharmaceutical compositions for the treatment of viral infections
View Patent ↗Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
1. A compound of the formula:
wherein
R Y is substituted alkyl;
R a and R b are selected as follows:
i) R a and R b are each independently hydrogen, alkyl, benzyl or substituted benzyl; and
R 2 and R 3 are each independently H, or R 2 and R 3 are linked to form a cyclic group by an alkyl, ester or carbamate linkage;
or a pharmaceutically acceptable salt, a stereoisomeric, or tautomeric form thereof.
2. The compound of claim 1 wherein R a and R b are independently hydrogen or benzyl.
3. The compound of claim 1 wherein R Y is —C(CH 3 ) 2 CH 2 OH.
4. The compound of claim 1 wherein R 2 and R 3 are each hydrogen, R a is hydrogen, R b is benzyl and R Y is —C(CH 3 ) 2 CH 2 OH.
5. A compound of the formula:
6. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient, carrier or diluent.
7. The composition of claim 6 , wherein the composition is an oral formulation.
8. A kit comprising a combination, wherein the combination comprises a compound of claim 1 or a pharmaceutically acceptable salt thereof, or a stereoisomeric or tautomeric form thereof, and ribavirin.
9. A The compound of claim 1 of the formula
or a pharmaceutically acceptable salt or stereoisomer thereof.
10. A pharmaceutical composition comprising a compound of claim 9 and a pharmaceutically acceptable excipient, carrier or diluent.