Nucleoside analogs
A purified compound having activity against hepatitis C virus is disclosed.
1. A purified compound represented by formula I or a purified compound represented by formula II, or a salt or pharmaceutically acceptable salt thereof:
wherein R is OMe, OEt, —N(—CH 2 CH 2 CH 2 —), or OH.
2. The purified compound of claim 1 represented by formula I
wherein R is OMe.
3. The purified compound of claim 1 represented by formula I
wherein R is OEt.
4. The purified compound of claim 1 represented by formula I
wherein R is OH.
5. The purified compound of claim 1 represented by formula I
wherein R is —N(—CH 2 CH 2 CH 2 —).
6. The purified compound of claim 1 represented by formula II
7. A pharmaceutical composition comprising the compound according to claim 1 .
8. A method of treatment of a subject infected with a virus selected from the group consisting of hepatitis C virus, West Nile virus, yellow fever virus, dengue virus, rhinovirus, polio virus, hepatitis A virus, bovine viral diarrhea virus or Japanese encephalitis virus which comprises administering to the subject a therapeutically effective amount of the compound according to claim 1 .
9. The method of treatment according to claim 8 wherein the virus is hepatitis C virus.
10. A method of treatment in a subject in need thereof, which comprises contacting at least one hepatitis C virus infected cell with at least one compound according to claim 1 .