Amino-substituted 8-N-benzimidazoles and methods for their use in blood sugar disorders
View Patent ↗The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
1. A method for the reduction of blood sugar levels comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula I
wherein:
R20 and R21 are each independently selected from the group consisting of H, (C 1 -C 6 )-alkylene-(C 6 -C 10 )-aryl and S(O) 2 -aryl, wherein the aryl groups are each optionally mono- or poly-substituted by F, Cl, Br, I, CN, NO 2 , SH, OH, (C 1 -C 6 )-alkyl, O-(C 1 -C 6 )-alkyl or S-(C 1 -C 6 )-alkyl;
R3 is selected from the group consisting of (C 2 -C 10 )-alkenyl and (C 1 -C 6 )-alkylene -(C 6 -C 10 )-aryl;
R4 and R5 are each H; and
R11 is selected from the group consisting of F, Cl, Br, I, (C 1 -C 6 )-alkyl, (C 3 -C 8 )-cycloalkyl, NH 2 , NH(C 1 -C 6 )-alkyl, NH(C 3 -C 7 )-cycloalkyl, N((C 1 -C 6 )-alkyl) 2 and O-(C 1 -C 6 )-alkyl, where the alkyl groups are optionally mono- or polysubstituted by F, Cl, Br or I; and
n is 0;
or a pharmaceutically acceptable salt thereof useful in the preparation of a pharmaceutical composition for the reduction of blood sugar levels.
2. The method as recited in claim 1 wherein the patient has diabetes.