METHODS OF TISSUE RECONFIGURATION

1 . An endoscopic treatment method, comprising:

introducing an endoscopic device into a lumen of a patient without creating an incision in the patient's skin;

introducing a treatment device into the lumen;

engaging a wall of the lumen with an end effecter of the endoscopic device;

forming at least one first plication in the wall of the lumen;

forming at least one second plication in the wall of the lumen adjacent the first plication;

coupling the first plication with the second plication to thereby form at least one first double plication;

wherein an open pocket is formed between the first plication and the second plication;

wherein the double plication is positioned in cooperative relationship with the patient's gastro-esophageal-junction so as to form an artificial gastric valve.

2 . An endoscopic treatment method, comprising:

introducing an endoscopic device into a lumen of a patient without creating an incision in the patient's skin;

introducing a treatment device into the lumen;

engaging a wall of the lumen with an end effecter of the endoscopic device;

forming at least one first plication in the wall of the lumen;

forming at least one second plication in the wall of the lumen adjacent the first plication;

coupling the first plication with the second plication to thereby form at least one first double plication, wherein an open pocket is formed between the first plication and the second plication; and

coupling an implant device with the first or second plication.

3 . The method of claim 2 , wherein the implant device is a drug delivery device.

4 . The method of claim 2 , wherein the implant device is selected from the group consisting of an electrical stimulation device, a mechanical stimulation device, a vibratory device, a sound device, an ultra-sound device, a chemical stimulation device, a neuro-transmitter stimulation device, a thermal stimulation device, a sensory stimulation device, and combinations thereof.

5 . An endoscopic treatment method, comprising:

introducing an endoscopic device into a lumen of a patient without creating an incision in the patient's skin;

introducing a treatment device into the lumen;

engaging a wall of the lumen with an end effecter of the endoscopic device;

forming at least first and second plications in the wall of the lumen such that at least first and second open pockets are formed in the wall of the lumen;

wherein the plications are adjacent, and wherein the open pockets are axially aligned.