Granted Patent
B2
US 7,713,525 · App. 11/877,234 · Granted May 11, 2010
Biomarkers for cancer sensitivity and uses thereof
Assignee:
The UAB Research Foundation
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Abstract
Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity.
Claims (5)
1. A method of predicting or monitoring the efficacy an anti-cancer agent in a subject with cancer comprising:
(a) administering the agent to the subject with cancer, wherein the agent is TRA-8 or an antibody having the same epitope specificity as TRA-8;
(b) acquiring a biological sample from the subject; and
(c) detecting levels of PGK1, an increase in levels compared to baseline levels indicating efficacy.
2. The method of claim 1 , wherein the antibody having the same epitope specificity as TRA-8 is a humanized version of TRA-8.
Assignments (3)
CONFIRMATORY LICENSE
Recorded Dec 20, 2018
From: UNIVERSITY OF ALABAMA AT BIRMINGHAM
To: NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR
Reel/Frame 047836/0458 →
CONFIRMATORY LICENSE
Recorded May 5, 2008
From: THE UNIVERSITY OF ALABAMA AT BIRMINGHAM
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 020898/0561 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 31, 2008
From: KIMBERLY, ROBERT P.; ZHOU, TONG; ISOYAMA, TAKESHI
To: UAB RESEARCH FOUNDATION, THE
Reel/Frame 020440/0617 →
Continuity (2)
Provisional Application
6086252700
· Oct 23, 2006