Methods and compositions for inhibition of viral replication
View Patent ↗The present invention is directed to methods and compositions that are effective in the inhibition of viral replication. In particular, the methods and compositions are effective at interfering with the activity of host cell proteins required in viral replication. For example, an embodiment of the invention is directed to methods and compositions comprising RNA sequences to which the host cell proteins TIAR and/or TIA-1 bind.
1. A composition comprising a RNA sequence selected from the group comprising a nucleic acid sequence having the nucleotide sequence of SEQ ID NO: 20, 21, 22, 23, 24, or 25.
2. The composition of claim 1 , wherein the RNA sequence comprises the nucleic acid sequence having the nucleotide sequence of SEQ ID NO: 20.
3. The composition of claim 1 , wherein the RNA sequence comprises the nucleic acid sequence having the nucleotide sequence of SEQ ID NO: 21.
4. The composition of claim 1 , wherein the RNA sequence comprises the nucleic acid sequence having the nucleotide sequence of SEQ ID NO: 22.
5. The composition of claim 1 , wherein the RNA sequence comprises the nucleic acid sequence having the nucleotide sequence of SEQ ID NO: 24.
6. The composition of claim 1 , wherein the RNA sequence comprises the nucleic acid sequence having the nucleotide sequence of SEQ ID NO: 25.
7. A composition comprising a RNA sequence which comprises the nucleic acid sequence having the nucleotide sequence of SEQ ID NO: 23.