Methods and compositions for treating proliferative diseases
The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
1. A method of treating a cancer disease in an individual, comprising administering to the individual an effective amount of a composition comprising nanoparticles comprising 17-AAG and an albumin, wherein the nanoparticles comprise 17-AAG coated with the albumin.
2. The method according to claim 1 , wherein the cancer is lung cancer.
3. The method according to claim 1 , wherein the 17-AAG is administered intravenously.
4. The method according to claim 1 , wherein the albumin is human serum albumin.
5. The method according to claim 1 , wherein the average diameter of the nanoparticles in the composition is no greater than 200 nm.
6. The method according to claim 1 , wherein the weight ratio of the albumin to 17-AAG in the composition is less than 18:1.
7. The method according to claim 4 , wherein the average diameter of the nanoparticles in the composition is no greater than 200 nm.
8. The method according to claim 7 , wherein the weight ratio of the albumin to 17-AAG in the composition is less than 18:1.
9. The method according to claim 1 , wherein the composition does not induce significant side effects.
10. The method according to claim 5 , wherein the average diameter of the nanoparticles in the composition is no greater than 100 nm.
11. The method according to claim 6 , wherein the weight ratio of the albumin to 17-AAG in the composition is about 3:1 to about 12:1.