Levalbuterol salt
Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.
1 - 29 . (canceled)
30 . Levalbuterol L-tartrate, which is a hemitartrate.
31 . A pharmaceutical composition comprising the levalbuterol L-tartrate of claim 30 .
32 . The pharmaceutical composition of claim 31 , which further comprises a propellant.
33 . The pharmaceutical composition of claim 32 , wherein the propellant is 1,1,1,2-tetrafluoroethane.
34 . The pharmaceutical composition of claim 31 , which further comprises a surfactant.
35 . The pharmaceutical composition of claim 34 , wherein the surfactant is oleic acid.
36 . The pharmaceutical composition of claim 31 , which further comprises a co-solvent.
37 . The pharmaceutical composition of claim 36 , wherein the co-solvent is ethanol.
38 . The pharmaceutical composition of claim 37 , wherein the ethanol is dehydrated ethanol.
39 . The pharmaceutical composition of claim 31 , which is adapted for administration by inhalation using a metered dose inhaler.
40 . The pharmaceutical composition of claim 39 , which is adapted for administration of from about 45 μg to about 90 μg levalbuterol free base per actuation.
41 . A pharmaceutical composition comprising levalbuterol L-tartrate, 1,1,1,2-tetrafluoroethane, oleic acid, and ethanol.
42 . The pharmaceutical composition of claim 41 , wherein the ethanol is dehydrated ethanol.
43 . The pharmaceutical composition of claim 42 , which is adapted for administration by inhalation using a metered dose inhaler.
44 . The pharmaceutical composition of claim 43 , wherein one gram of the composition contains about 1.04 mg of levalbuterol L-tartrate, about 0.951 g of 1,1,1,2-tetrafluoroethane, about 0.0521 mg of oleic acid, and about 0.0476 g of dehydrated ethanol.
45 . The pharmaceutical composition of claim 43 , wherein one gram of the composition contains about 2.08 mg of levalbuterol L-tartrate, about 0.95 g of 1,1,1,2-tetrafluoroethane, about 0.104 mg of oleic acid, and about 0.0475 g of dehydrated ethanol.