Fluorescent chlorotoxin conjugate and method for intra-operative visualization of cancer
A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.
1. A chlorotoxin conjugate, comprising a cyanine moiety covalently coupled to a chlorotoxin.
2. The conjugate of claim 1 , wherein the chlorotoxin is selected from the group consisting of native chlorotoxin, synthetic chlorotoxin, and recombinant chlorotoxin.
3. The conjugate of claim 1 , wherein the conjugate comprises from one to three cyanine moieties covalently coupled to the chlorotoxin.
4. A chlorotoxin conjugate, consisting of from one to three cyanine moieties covalently coupled to a chlorotoxin.
5. The conjugate of claim 4 , wherein the chlorotoxin is selected from the group consisting of native chlorotoxin, synthetic chlorotoxin, and recombinant chlorotoxin.
6. A chlorotoxin conjugate, consisting of a cyanine moiety covalently coupled to a chlorotoxin.
7. The conjugate of claim 6 , wherein the chlorotoxin is selected from the group consisting of native chlorotoxin, synthetic chlorotoxin, and recombinant chlorotoxin.
8. A composition, comprising a pharmaceutically acceptable carrier and a chlorotoxin conjugate, wherein the conjugate comprises a cyanine moiety covalently coupled to a chlorotoxin.
9. The composition of claim 8 , wherein the chlorotoxin is selected from the group consisting of native chlorotoxin, synthetic chlorotoxin, and recombinant chlorotoxin.
10. The composition of claim 8 , wherein the conjugate comprises from one to three cyanine moieties.
11. A composition, comprising a pharmaceutically acceptable carrier and a chlorotoxin conjugate, wherein the conjugate consists of from one to three cyanine moieties covalently coupled to a chlorotoxin.
12. The composition of claim 11 , wherein the chlorotoxin is selected from the group consisting of native chlorotoxin, synthetic chlorotoxin, and recombinant chlorotoxin.
13. A composition, comprising a pharmaceutically acceptable carrier and a chlorotoxin conjugate, wherein the conjugate consists of a cyanine moiety covalently coupled to a chlorotoxin.
14. The composition of claim 13 , wherein the chlorotoxin is selected from the group consisting of native chlorotoxin, synthetic chlorotoxin, and recombinant chlorotoxin.