Monoclonal antibodies with binding specificity for response gene to complement 32 (RGC-32)
The invention relates to antibodies that bind to a fragment of the Response Gene to Complement-32 (RGC-32), as well as methods of using these antibodies. Particular methods of using the antibodies of the present invention include, but are not limited to, methods of detecting RGC-32 in a sample, methods of assaying cell proliferation, as well as methods of detecting and/or monitoring the progression of abnormal conditions in a subject, where the disease states are associated with the presence or absence of RGC-32.
1. An isolated antibody that specifically binds to the amino acid sequence of SEQ ID NO:1, wherein said antibody is a monoclonal antibody.
2. The antibody of claim 1 , wherein said antibody is a single chain antibody.
3. The antibody of claim 1 , wherein said antibody is a single chain Fv (scFv) fragment.
4. The antibody of claim 1 , wherein said antibody is a Fab fragment.
5. The antibody of claim 1 , wherein said antibody is a humanized antibody.
6. The antibody of claim 1 , wherein said antibody is a chimeric antibody.
7. A composition comprising the antibody of claim 1 and a carrier.
8. A method of detecting an antigen in a biological sample, said method comprising contacting said biological sample with the antibody of claim 1 , and detecting the binding of said antibody to said antigen, wherein detectable binding is indicative of the presence of said antigen in said biological sample.
9. The method of claim 8 , wherein said antibody is a single chain antibody.
10. The method of claim 8 , wherein said antibody is a single chain Fv (scFv) fragment.
11. The method of claim 8 , wherein said antibody a Fab fragment.
12. The method of claim 8 , wherein said antibody a humanized antibody.
13. The method of claim 8 , wherein said antibody a chimeric antibody.