Prognosis and treatment of breast cancer
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival and select treatment modalities for breast cancer. The present invention is also a method for inducing apoptosis in breast cancer cells by inhibiting the expression or activity of Spot 14. Compositions and methods for treating breast cancer are also provided.
1. A method of predicting disease-free survival of a subject with breast cancer comprising detecting the expression level of S14 consisting of SEQ ID NO: 1 in a sample obtained from a subject with breast cancer, comparing the level in the sample with a control sample, and determining whether the expression level of S14 consisting of SEQ ID NO: 1 in the sample obtained from the subject with breast cancer is comparable to the expression level of S14 consisting of SEQ ID NO: 1 in the control sample wherein a lack of overexpression of S14 consisting of SEQ ID NO: 1 in the sample compared to the control is predictive of disease-free survival.