Therapeutic compositions
View Patent ↗The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features pharmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.
1. A method of formulating an orally administered therapeutic agent for increased oral bioavailability of the therapeutic agent in a subject, the method comprising
a. combining in a pharmaceutical composition a biopolymer, a therapeutic agent and an absorption enhancer consisting of a Ceteth-12 polyoxyethylene alkyl ether; and
b. formulating a therapeutically effective amount of the pharmaceutical composition in a dosage form suitable for oral administration to a subject in need thereof.
2. The method of claim 1 , wherein the pharmaceutical composition results in an oral bioavailability of the therapeutic agent in the subject that is at least about 1.5 times greater than the bioavailability of the therapeutic agent in the subject when the therapeutic agent is orally administered to the subject in the absence of the absorption enhancer.
3. The method of claim 1 , wherein the molar ratio of the therapeutic agent to the biopolymer in the pharmaceutical composition is about 5:1 to 1:5.
4. The method of claim 1 , wherein the weight ratio of the absorption enhancer to the therapeutic agent in the pharmaceutical composition is about 10:1 to 1:2.
5. The method of claim 1 , wherein the weight ratio of the absorption enhancer to the therapeutic agent in the pharmaceutical composition is about 2:1 to 4:1.
6. The method of claim 1 , wherein the weight ratio of the absorption enhancer to the combination of the biopolymer and the therapeutic agent in the pharmaceutical composition is 2:1 to 4:1.
7. The method of claim 1 , wherein the biopolymer is present in the pharmaceutical composition from about 5% to 35% by weight.
8. The method of claim 1 , wherein the biopolymer is selected from the group consisting of a polysaccharide, a polycarbophil and a carbopol.
9. The method of claim 8 , wherein the polysaccharide is a carrageenan.
10. The method of claim 1 , wherein
a. the biopolymer is a polycarbophil; and
b. the weight ratio of the absorption enhancer to the therapeutic agent in the pharmaceutical composition is about 2:1.
11. The method of claim 10 , wherein
a. the weight ratio of the absorption enhancer to the combination of the biopolymer and the therapeutic agent in the pharmaceutical composition is about 2:1 to 4:1; and
b. the biopolymer is present in the pharmaceutical composition from about 5% to 35% by weight.
12. The method of claim 1 , wherein the pharmaceutical composition results in an oral bioavailability of the therapeutic agent in the subject that is greater than the oral bioavailability of the therapeutic agent in the subject when the therapeutic agent is orally administered to the subject in the absence of the biopolymer.
13. The method of claim 1 , further comprising combining the biopolymer with the therapeutic agent to form a complex in a solution before combination with the absorption enhancer to form the pharmaceutical composition.
14. The method of claim 13 , further comprising freezing and lyophilizing the complex prior to combination with the absorption enhancer to form the pharmaceutical composition.
15. The method of claim 1 , wherein the pharmaceutical composition results in an oral bioavailability of the therapeutic agent in the subject that is at least about 10 times greater than the oral bioavailability of the therapeutic agent in the subject when the therapeutic agent is orally administered to the subject in the absence of the absorption enhancer.
16. A method of formulating an orally administered therapeutic agent for increased oral bioavailability of the therapeutic agent in a subject, the method comprising
a. combining in a pharmaceutical composition a biopolymer, a cephalosporin therapeutic agent and an absorption enhancer consisting essentially of a polyoxyethylene alkyl ether having the formula C 16 H 34 (OCH 2 CH 2 ) n OH where n is 4 to 23; and
b. formulating a therapeutically effective amount of the pharmaceutical composition in a dosage form suitable for oral administration to a subject in need thereof.
17. The method of claim 16 , wherein the pharmaceutical composition results in an oral bioavailability of the therapeutic agent in a subject that is greater than the bioavailability of the therapeutic agent the subject when the therapeutic agent is orally administered to the subject in the absence of the biopolymer.
18. The method of claim 16 , further comprising combining the biopolymer with the therapeutic agent to form a complex in a solution before combination with the absorption enhancer to form the pharmaceutical composition.
19. The method of claim 18 , further comprising freezing and lyophilizing the complex prior to combination with the absorption enhancer to form the pharmaceutical composition.
20. The method of claim 16 , wherein the pharmaceutical composition results in an oral bioavailability of the therapeutic agent in the subject that is at least about 1.5 times greater than the oral bioavailability of the therapeutic agent in the subject when the therapeutic agent is orally administered to the subject in the absence of the absorption enhancer.
21. A method of treatment comprising orally administered to a subject a therapeutically effective amount of a pharmaceutical composition consisting essentially of a biopolymer, a therapeutic agent and an absorption enhancer consisting essentially of a Ceteth-12 polyoxyethylene alkyl ether.
22. The method of claim 21 , wherein the pharmaceutical composition is produced by
a. combining the biopolymer with a cephalosporin therapeutic agent to form a complex of the biopolymer and the cephalosporin therapeutic agent;
b. combining in a pharmaceutical composition the complex and the polyoxyethylene alkyl ether absorption enhancer; and
c. formulating a therapeutically effective amount of the pharmaceutical composition in a dosage form suitable for administration to a subject in need thereof.
23. The method of claim 21 , wherein the weight ratio of the absorption enhancer to the complex in the pharmaceutical composition is about 1:1 to 4:1.
24. The method of claim 21 , wherein the weight ratio of the therapeutic agent to the absorption enhancer in the pharmaceutical composition is about 2:1.
25. The method of claim 21 , wherein the biopolymer is a polycarbophil.
26. The method of claim 25 , wherein the weight ratio of the therapeutic agent to the absorption enhancer in the pharmaceutical composition is about 2:1.