Method for increasing cardiac mass and performance
The present invention relates to methods of using a proline/arginine-rich peptide such as PR11 or PR39 for increasing cardiac mass or performance and in the treatment of heart failure.
1. A method for increasing cardiac mass or performance in a subject comprising administering an effective amount of a purified proline/arginine-rich peptide comprising the amino acid sequence of SEQ ID NO:4 to a subject for at least six weeks and determining an increase in cardiac mass of at least 35% and an increase in systolic and/or diastolic performance in the subject.
2. A method for treating heart failure in a subject comprising administering an effective amount of a purified proline/arginine-rich peptide comprising the amino acid sequence of SEQ ID NO:4 to a subject for at least six weeks and determining an increase in cardiac mass of at least 35% and an increase in systolic and/or diastolic performance in the subject, thereby treating heart failure in the subject.