IP Library Granted Patent US 8,227,244
Granted Patent B2
US 8,227,244 · App. 11/914,402 · Granted Jul 24, 2012

Method for isolating dermal papilla cells and uses thereof

Assignee: The Rockefeller University
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Quick Facts
Patent No.
US 8,227,244
App. No.
11/914,402
Granted
Jul 24, 2012
Kind
B2
Abstract

The present invention relates to dermal papilla-specific markers and a method for isolating dermal papilla cells using the same. Dermal papilla cells isolated in accordance with the method of the invention and treated with BMP6 are useful for promoting hair growth.

Claims (7)

1. A method for isolating dermal papilla cells comprising

(a) obtaining a population of cells comprising dermal papilla cells;

(b) sorting the population of cells by

(i) removing cells that express CD34,

(ii) removing cells that express CD45, and

(iii) removing cells that express CD117 to obtain a population of cells that are CD34 − , CD45 − and CD117 − ; and

(c) isolating from the population of CD34 − , CD45 − and CD117 − cells, a population of cells that express Hhip, Frzb, Pdgfra, Tgfbr1, Vcam1, Itga9, Epha7, and Efnb3, thereby isolating dermal papilla cells.

Assignments (3)
CONFIRMATORY LICENSE Recorded Sep 23, 2019
From: THE ROCKEFELLER UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR
Reel/Frame 050461/0293 →
CONFIRMATORY LICENSE Recorded May 14, 2008
From: THE ROCKEFELLER UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 020944/0287 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 22, 2008
From: FUCHS, ELAINE; RENDL, MICHAEL
To: THE ROCKEFELLER UNIVERSITY
Reel/Frame 020546/0720 →
Continuity (1)
Related Publication 20080213882A1 · Sep 4, 2008