Agent for treatment of liver diseases containing pyrazolopyrimidinone derivative
The present invention relates to the pharmaceutical composition for prevention and treatment of liver diseases containing pyrazolopyrimidine derivative as an active ingredient. According to the present invention, pyrazolopyrimidine derivative has an excellent effect on inhibiting collagen synthesis in hepatic stellate cells and acts directly on the portal vein. Particularly, it may increase the diameter and the amount of blood flow of the portal vein, and finally decrease the pressure thereof. Therefore, pyrazolopyrimidine derivative can be used advantageously for prevention and treatment of hepatic fibrosis, liver cirrhosis caused by hepatic fibrosis, portal hypertension and various complications caused by portal hypertension. In addition, pyrazolopyrimidine derivative according to the present invention can reduce dosing frequency because of its long half-life, and therefore, has an advantage to improve the drug compliance of patients suffering from chronical liver diseases.
1. A method of reducing hepatic fibrosis in a mammal comprising administering an effective amount of a pyrazolopyrimidinone having Formula I:
to a mammal in need thereof.
2. A method of inhibiting collagen synthesis in a mammal comprising administering an effective amount of a pyrazolopyrimidinone having Formula I:
to a mammal in need thereof.
3. A method for inhibiting hepatic portal hypertension in a mammal comprising administering an effective amount of a pyrazolopyrimidinone having Formula I:
to a mammal in need thereof.
4. A method for treating a complication caused by hepatic portal hypertension in a mammal comprising administering an effective amount of a pyrazolopyrimidinone having Formula I:
to a mammal in need thereof, wherein the complication is selected from the group consisting of esophageal varices, splenic enlargement, hypersplenism, ascites, spontaneous bacterial peritonitis, hepatorenal syndrome, hepatopulmonary syndrome and hepatic encephalopathy.