Dental mineralization

1. A method for reducing white spot lesions on tooth enamel comprising administering a bleach, a protease, or a mixture of proteases to the enamel prior to contacting the enamel with a phosphopeptide-stabilized amorphous calcium phosphate (ACP) and/or amorphous calcium fluoride phosphate (AFCP).

2. A method according to claim 1 , wherein the bleach is sodium hypochlorite or a carbamide peroxide bleach.

3. A method according to claim 1 , wherein the protease or mixture of proteases comprises a protease selected from the group consisting of endopeptidases, proteinases, exopeptidases, and combinations thereof.

4. A method according to claim 1 , wherein the white spot lesion is caused by dental caries, dental erosion or fluorosis.

5. A method according to claim 1 , wherein the phosphopeptide is a casein phosphopeptide.

6. A method according to claim 1 , wherein the ACP or ACFP is in a basic phase.

7. A kit for the treatment of a white spot lesion including:

(a) a first composition comprising a bleach, a protease or a mixture of proteases; and

(b) a second composition comprising a phosphopeptide-stabilized ACP or ACFP complex in a pharmaceutically acceptable carrier, and

written instructions, wherein the written instructions direct the user to administer the first composition prior to the second composition.

8. A kit according to claim 7 , wherein the bleach is sodium hypochlorite or a carbamide peroxide bleach.

9. A kit according to claim 7 , wherein the protease or mixture of proteases comprises a protease selected from the group consisting of endopeptidases, proteinases, exopeptidases, and combinations thereof.

10. A kit according to claim 7 , wherein the white spot lesion is caused by dental caries, dental erosion or fluorosis.

11. A kit according to claim 7 , wherein the phosphopeptide is a casein phosphopeptide.

12. A kit according to claim 7 , wherein the ACP or ACFP is in a basic phase.