Modified malonate derivatives

1. A compound represented by the following structural Formula:

wherein Y 1 and Y 2 are, independently of each other, hydrogen, a substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 1 -C 10 alkenyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl;

w is 1 or 2, wherein when w is 2, the two Y 1 are the same or different;

z is 1 or 2, wherein when z is 2, the two Y 2 are the same or different;

v, j, k, g are independently of each other 0, 1, 2, 3 or 4, wherein v+j+k+g is less or equal to 4;

h, q, m, r are independently of each other 0, 1, 2, 3 or 4, wherein h+q+m+r is less or equal to 4;

when j is not 0, A 2 is selected from —NH—, —S—, —O—, ethenyl or a bond; when j is 0, A 2 is a bond or ethenyl;

when m is not 0, A 1 is selected from —NH—, —S—, —O—, ethenyl or a bond; when m is 0, A 1 is a bond or ethenyl;

n is 0, 1, 2, 3 or 4;

R 1 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl, halo, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl;

R 2 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl or halo;

s is 1 or 2, and when s is 2, R 2 is the same or different;

R 9 , R 10 , R 13 and R 14 are independently of each other selected from hydrogen or C 1 -C 4 alkyl;

R 11 and R 12 are independently of each other selected from hydrogen, C 1 -C 4 alkyl, or halo;

R 8 and R 15 are independently of each other selected from hydrogen, C 1 -C 4 alkyl, OH, or halo;

R 6 and R 7 are independently of each other hydrogen or C 1 -C 4 alkyl;

Ring B is cycloalkyl, heteroaryl, heterocyclic or aryl;

R 3 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, —NHSO 2 , —SO 2 NH, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino;

t is 1, 2, 3 or 4;

L 1 is (CH 2 ) r , ethenyl or cyclopropyl, wherein r is 0, 1 or 2;

Ring A is a 5 to 6 membered heteroaryl or aryl;

X is OH, SH or NH 2 ;

p is 1,2, 3 or 4;

R 5 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino or L 2 -R 16 , wherein R 16 is substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, L 2 is selected from a bond, C 1 -C 4 alkylene, C 1 -C 4 alkynyl, C 1 -C 4 alkenyl, —O—, —S—, —N—, —C(═O)NH—, —NHC(═O)—, —NHC(═O)NH—, —SO 2 NH—, —NHSO 2 —, —SO 2 —, —C(═O)— or —C(═O)O—;

or a stereoisomer or pharmaceutically acceptable salt thereof.

2. The compound of claim 1 represented by the following structural Formula:

wherein Y 1 and Y 2 are, independently of each other, hydrogen, a substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 1 -C 10 alkenyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl;

w is 1 or 2, wherein when w is 2, the two Y 1 are the same or different;

z is 1 or 2, wherein when z is 2, the two Y 2 are the same or different;

j and m are independently of each other 0, 1, 2, 3 or 4;

when j is not 0, A 2 is selected from —NH—, —S—, —O—, ethenyl or a bond; when j is 0, A 2 is a bond or ethenyl;

when m is not 0, A 1 is selected from —NH—, —S—, —O—, ethenyl or a bond; when m is 0, A 1 is a bond or ethenyl;

n is 0, 1, 2, 3 or 4;

R 1 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl, halo, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl;

R 2 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl or halo;

s is 1 or 2, and when s is 2, R 2 is the same or different;

R 9 and R 14 are independently of each other selected from hydrogen or C 1 -C 4 alkyl;

Ring B is cycloalkyl, heteroaryl, heterocyclic or aryl;

R 3 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, —NHSO 2 , —SO 2 NH, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino;

t is 1,2, 3 or 4;

L 1 is (CH 2 ) r , cyclopropyl, or ethenyl, wherein r is 0, 1 or 2;

Ring A is a 5 to 6 membered heteroaryl or aryl;

X is OH, SH or NH 2 ;

p is 1,2, 3 or 4;

R 5 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino or L 2 -R 16 , wherein R 16 is substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, L 2 is selected from a bond, C 1 -C 4 alkylene, C 1 -C 4 alkynyl, C 1 -C 4 alkenyl, —O—, —S—, —N—, —C(═O)NH—, —NHC(═O)—,

—NHC(═O)NH—, —SO 2 NH—, —NHSO 2 —, —SO 2 —, —C(═O)— or —C(═O)O—;

or a stereoisomer or pharmaceutically acceptable salt thereof.

3. The compound of claim 1 represented by the following structural formula:

wherein Y 1 and Y 2 are, independently of each other, hydrogen, a substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 1 -C 10 alkenyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl;

w is 1 or 2, wherein when w is 2, the two Y 1 are the same or different;

z is 1 or 2, wherein when z is 2, the two Y 2 are the same or different;

j and m are independently of each other 0, 1, 2, 3 or 4;

when j is not 0, A 2 is selected from —NH—, —S—, —O—, ethenyl or a bond; when k is 0, A 2 is a bond or ethenyl;

when m is not 0, A 1 is selected from —NH—, —S—, —O—, ethenyl or a bond; when m is 0, A 1 is a bond or ethenyl;

n is 0, 1, 2, 3 or 4;

R 1 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl, halo, substituted or unsubstituted aryl;

R 2 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl or halo;

R 9 and R 14 are independently of each other selected from hydrogen or C 1 -C 4 alkyl;

Ring B is heteroaryl or aryl;

R 3 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino;

L 1 is (CH 2 ) r , cyclopropyl, or ethenyl, wherein r is 0, 1 or 2;

X is OH, SH or NH 2 ;

R 17 , R 18 and R 20 are independently of each other selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, —NHSO 2 , —SO 2 NH, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino;

R 19 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, —NHSO 2 , —SO 2 NH, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino or L 2 -R 16 , wherein R 16 is substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, L 2 is selected from a bond, C 1 -C 4 alkylene, C 1 -C 4 alkynyl, C 1 -C 4 alkenyl, —O—, —S—, —N—, —C(═O)NH—, —NHC(═O)—,

—NHC(═O)NH—, —SO 2 NH—, —NHSO 2 —, —SO 2 —, —C(═O)— or —C(═O)O—;

or a stereoisomer or pharmaceutically acceptable salt thereof.

4. The compound of claim 3 , wherein Y 1 and Y 2 are, independently of each other, a substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted aryl.

5. The compound of claim 4 , wherein Y 1 and Y 2 are, independently of each other, an optionally substituted phenyl, indolyl, quinolinyl, pyridyl, biphenyl, naphthyl, thiazolyl, pyrrolidinyl, benzodioxinyl, said optional substituent comprises one, two or three groups selected from hydroxyl, halo, amino, nitro, CN, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 alkylamino, di(C 1 -C 4 )alkylamino, C 1 -C 4 alkyl-NHS(O) 2 —, C 1 -C 4 alkyl-S(O) 2 NH—, aryl C 1 -C 4 alkoxy, heterocyclic, aryl or heteroaryl.

6. The compound of claim 3 , wherein Ring B is selected from phenyl, benzothiophenyl, benzofuranyl, thiazolyl, benzothiazolyl, furanyl, pyridyl, pyrimidyl, quinolinyl, thiophenyl, benzodioxyl, benzooxadiazolyl, quinoxalinyl, benzotriazolyl, benzoimidazolyl or benzooxazolyl.

7. The compound of claim 3 , wherein R 19 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 4 alkoxy, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 hydroxyalkyl, C 1 -C 4 alkenyl, C 1 -C 4 alkyl-C(═O)O—, C 1 -C 4 alkynyl, halo group, amide or L 2 -R 16 , wherein R 16 is substituted or unsubstituted heteroaryl, substituted or unsubstituted aryl, L 2 is selected from a bond, ethylene, ethenyl, ethynyl, —O—, —S—, —C(═O)NH—, —NHC(═O)—, —C(═O)— or —C(═O)O—.

8. The compound of claim 7 , wherein R 17 , R 18 and R 20 are independently of each other hydrogen or fluoro.

9. The compound of claim 8 , wherein R 19 is hydrogen or phenyl and X is amino.

10. The compound of claim 3 , wherein w and z are 1, R 9 and R 14 are hydrogen, and A 1 and A 2 are each a bond.

11. The compound of claim 1 represented by the following structural formula:

wherein Y 1 and Y 2 are, independently of each other, hydrogen, a substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 1 -C 10 alkenyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl;

w is 1 or 2, wherein when w is 2, the two Y 1 are the same or different;

z is 1 or 2, wherein when z is 2, the two Y 2 are the same or different;

j and m are independently of each other 0, 1, 2, 3 or 4;

when j is not 0, A 2 is selected from —NH—, —S—, —O—, ethenyl or a bond; when k is 0, A 2 is a bond or ethenyl;

when m is not 0, A 1 is selected from —NH—, —S—, —O—, ethenyl or a bond; when m is 0, A 1 is a bond or ethenyl;

n is 0, 1, 2, 3 or 4;

R 1 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl, halo, substituted or unsubstituted aryl;

R 2 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl or halo;

R 9 and R 14 are independently of each other selected from hydrogen or C 1 -C 4 alkyl;

Ring B is heteroaryl or aryl;

R 3 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino;

L 1 is (CH 2 ) r , cyclopropyl, or ethenyl, wherein r is 0, 1 or 2;

X is OH, SH or NH 2 ;

R 17 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide; hydroxyalkoxy, —NHSO 2 , —SO 2 NH, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino;

R 19 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, —NHSO 2 , —SO 2 NH, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino or L 2 -R 16 , wherein R 16 is substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, L 2 is selected from a bond, C 1 -C 4 alkylene, C 1 -C 4 alkynyl, C 1 -C 4 alkenyl, —O—, —S—, —N—, —C(═O)NH—, —NHC(═O)—,

—NHC(═O)NH—, —SO 2 NH—, —NHSO 2 —, —SO 2 —, —C(═O)— or —C(═O)O—;

or a stereoisomer or pharmaceutically acceptable salt thereof.

12. A compound represented by the following structural Formula:

wherein Y 1 is selected from hydrogen, a substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 1 -C 10 alkenyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl; or Y 1 and R 7 are combined to form a substituted or unsubstituted C 1 -C 10 alkylene;

wherein Y 2 is selected from hydrogen, a substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 1 -C 10 alkenyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl;

or Y 2 and R 6 are combined to form a substituted or unsubstituted C 1 -C 10 alkylene;

w is 1 or 2, wherein when w is 2, the two Y 1 are the same or different;

z is 1 or 2, wherein when z is 2, the two Y 2 are the same or different;

j and m are independently of each other 0, 1, 2, 3 or 4;

when j is not 0, A 2 is selected from —NH—, —S—, —O—, ethenyl or a bond; when j is 0, A 2 is a bond or ethenyl;

when m is not 0, A 1 is selected from —NH—, —S—, —O—, ethenyl or a bond; when m is 0, A 1 is a bond or ethenyl;

n is 0, 1, 2, 3 or 4;

R 1 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl, halo, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, substituted or unsubstituted C 1 -C 10 alkylheteroaryl, substituted or unsubstituted C 1 -C 10 alkylheterocyclic or substituted or unsubstituted C 1 -C 10 alkylaryl;

R 2 is selected from hydrogen, OH, NH 2 , C 1 -C 4 alkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, substituted or unsubstituted C 1 -C 10 alkylheteroaryl, substituted or unsubstituted C 1 -C 10 alkylheterocyclic, substituted or unsubstituted C 1 -C 10 alkylaryl or halo;

s is 1 or 2, and when s is 2, R 2 is the same or different;

R 9 and R 14 are independently of each other selected from hydrogen or C 1 -C 4 alkyl;

Ring B is cycloalkyl, heteroaryl, heterocyclic or aryl;

R 3 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino;

t is 1, 2, 3 or 4;

L 1 is (CH 2 ) r , cyclopropyl, or ethenyl, wherein r is 0, 1 or 2;

Ring A is a 5 to 6 membered heteroaryl or aryl;

X is OH, SH or NH 2 ;

p is 1,2, 3 or 4;

R 5 is selected from hydrogen, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, —NHSO 2 , —SO 2 NH, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino or L 2 -R 16 , wherein R 16 is substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, L 2 is selected from a bond, C 1 -C 4 alkylene, C 1 -C 4 alkynyl, C 1 -C 4 alkenyl, —O—, —S—, —N—, —C(═O)NH—, —NHC(═O)—,

—NHC(═O)NH—, —SO 2 NH—, —NHSO 2 —, —SO 2 —, —C(═O)— or —C(═O)O—;

R 6 and R 7 are independently of each other hydrogen or C 1 -C 4 alkyl;

or a stereoisomer or pharmaceutically acceptable salt thereof.

13. The compound of claim 1 , wherein

X is OH, SH or NH 2 ;

R 30 is selected from hydrogen or halo;

R 31 is selected from hydrogen, C 1 -C 7 alkyl, or L 2 -R 29 , wherein R 29 is substituted or unsubstituted heteroaryl, substituted or unsubstituted aryl, L 2 is selected from a bond or C 1 -C 4 alkylene.

14. The compound of claim 13 , wherein R 31 is

R 32 and R 36 are independently selected from hydrogen or fluoro;

R 33 , R 34 or R 35 are independently selected from hydrogen, halo, methyl, methoxy or halomethyl.

15. A compound selected from:

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-dibenzylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(4-methoxybenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[2-(1H-indol-3-yl)ethyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[4-(dimethylamino)phenyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-diquinolin-8-ylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(2-pyridin-4-ylethyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-dimethylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-methoxyphenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[3-(trifluoromethyl)phenyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-di-2,3-dihydro-1,4-benzodioxin-6-ylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(4-fluorophenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-fluorophenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-chlorophenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(4-phenyl-1,3-thiazol-2-yl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[3-fluoro-5-(trifluoromethyl)phenyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(2-chlorophenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[4-(1H-1,2,4-triazol-1-yl)phenyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis{5-[(diethylamino)sulfonyl]-2-methoxyphenyl}malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-cyanophenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-di-1-naphthylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[2-(1H-pyrrol-1-yl)phenyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3,4,5-trimethoxyphenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(4-methyl-1,3-thiazol-2-yl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(4-morpholin-4-ylphenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[2-(4-methoxyphenyl)ethyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[2-(3,5-dimethoxyphenyl)ethyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-phenylpropyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(2-phenoxyethyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[2-(4-fluorophenyl)ethyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(4-tert-butylbenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-methoxybenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3,5-dimethoxybenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-fluorobenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[3-(trifluoromethyl)benzyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[3-fluoro-5-(trifluoromethyl)benzyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-chlorobenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(biphenyl-3-ylmethyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-hydroxybenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis[3-(1H-pyrrol-1-yl)benzyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-diisobutylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(2-fluorophenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(2-methylphenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(2-methoxyphenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(3-methylisoxazol-5-yl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-diisoxazol-3-ylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-bis(1,1-dimethylethyl)propanediamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-2-hydroxy-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-2-methyl-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-2-fluoro-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-2-(4-methoxybenzyl)-N,N′-diphenylmalonamide;

2-(5-{[(2-aminophenyl)amino]carbonyl}-2-pyridinyl)-2-hydroxy-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis(4-methoxyphenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis(3-fluorophenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis[3-(trifluoromethyl)phenyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-dibenzylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis(4-fluorobenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis(4-methylbenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis(3,4-dimethoxybenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis[4-(trifluoromethyl)benzyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis[4-(dimethylamino)benzyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis(4-methoxybenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis(1-phenylethyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis[1-(4-fluorophenyl)ethyl]malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-di-2,3-dihydro-1H-inden-1-ylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-bis(3,4-difluorobenzyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-2-methyl-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-dibenzyl-2-fluoromalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)-N,N′-dibenzyl-2-methylmalonamide;

2-(5-{[(2-aminophenyl)amino]carbonyl}pyridin-2-yl)-N,N′-diphenylmalonamide;

2-[(5-{[(2-aminophenyl)amino]carbonyl}-2-furyl)methyl]-N,N′-diphenylmalonamide;

2-(5-{[(2-aminophenyl)amino]carbonyl}-1,3-thiazol-2-yl)-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}-3-bromobenzyl)-N,N′-diphenylmalonamide;

2-(2-{[(2-aminophenyl)amino]carbonyl}-1-benzothien-6-yl)-N,N′-diphenylmalonamide;

2-[6-(2-Amino-phenylcarbamoyl)-thieno[2,3-d]pyrimidin-2-yl]-N,N′-diphenyl-malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}-3-vinylbenzyl)-N,N′-diphenylmalonamide;

2-{4-{[(2-aminophenyl)amino]carbonyl}-3-[(methylsulfonyl)amino]benzyl}-N,N′-diphenylmalonamide;

2-[1-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)ethyl]-N,N′-diphenylmalonamide;

2-[(4-{[(2-aminophenyl)amino]carbonyl}phenyl)(1-piperidinyl)methyl]-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}-2-methoxybenzyl)-N,N′-diphenylmalonamide;

2-(4-{3-[(2-aminophenyl)amino]-3-oxopropyl}phenyl)-N,N′-diphenylmalonamide;

2-(Quinolin-8-ylcarbamoyl)-octanedioic acid 8-[(2-amino-phenyl)-amide]1-quinolin-8-ylamide;

2-(Quinolin-6-ylcarbamoyl)-octanedioic acid 8-[(2-amino-phenyl)-amide]1-quinolin-6-ylamide;

2-(2-{[(2-aminophenyl)amino]carbonyl}-1-benzothien-6-yl)-N,N′-dibenzylmalonamide;

2-[1-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)ethyl]-N,N′-bis(4-fluorophenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-(3-cyanophenyl)-N′-phenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-benzyl-N′-(3-cyanophenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-(3-methoxyphenyl)-N′-phenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-benzyl-N′-(3-methoxyphenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-(3-cyanophenyl)-N′-(2-methoxy-1-methylethyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-(3-fluorobenzyl)-N′-(3-methoxyphenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-(3-chlorobenzyl)-N′-(3-methoxyphenyl)-N-methylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-ethyl-N-methyl-N′-phenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N-dimethyl-N′-phenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-methyl-N′-phenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-(3-fluorophenyl)-N′-phenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-phenyl-N′-(2-phenethyl)malonamide;

N-(2-aminophenyl)-4-[2-anilino-1-(morpholin-4-ylcarbonyl)-2-oxoethyl]benzamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-(2-methoxyphenyl)-N′-phenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-phenyl-N′-(3,4,5-trimethoxyphenyl)malonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-phenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N,N′-dimethyl-N,N′-diphenylmalonamide;

2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-N-methyl-N,N′-diphenylmalonamide;

2-(4-{[(4-hydroxybiphenyl-3-yl)amino]carbonyl})phenyl)-N,N′-diphenylmalonamide;

2-(4-{[(4-hydroxybiphenyl-3-yl)amino]carbonyl}benzyl)-N,N′-diphenylmalonamide;

2-(4-{[(4-amino-3-biphenylyl)amino]carbonyl}phenyl)-N,N′-diphenylmalonamide;

2-(4-{[(4-amino-3-biphenylyl)amino]carbonyl}benzyl)-N,N′-diphenylmalonamide;

2-(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}phenyl)-N,N-dimethyl-N′-phenylmalonamide;

2-(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}phenyl)-N-ethyl-N-methyl-N′-phenylmalonamide;

N-(4-aminobiphenyl-3-yl)-4-[2-anilino-1-(morpholin-4-ylcarbonyl)-2-oxoethyl]benzamide;

2-(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}phenyl)-N-(2-methoxyphenyl)-N′-phenylmalonamide;

2-(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}phenyl)-N-phenylmalonamide;

2-(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}phenyl)-N,N′-diisoxazol-3-ylmalonamide;

2-(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}phenyl)malonamide;

2-(4-{[(4-amino-3-biphenylyl)amino]carbonyl}-2-methoxybenzyl)-N,N′-diphenylmalonamide;

2-(5-{[(4-amino-3-biphenylyl)amino]carbonyl}-2-pyridinyl)-N,N′-diphenylmalonamide;

2-[4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}benzyl)-N,N′-bis(4-fluorobenzyl)malonamide;

2-[4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}benzyl)-N,N′-dibenzylmalonamide;

2-(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}benzyl)-N,N′-bis(1-phenylethyl)malonamide;

2-[4-({[2-amino-5-(2-thienyl)phenyl]amino}carbonyl)phenyl]-N-phenylmalonamide;

2-[4-({[2-amino-5-(2-thienyl)phenyl]amino}carbonyl)phenyl]malonamide;

2-[4-({[2-amino-5-(2-thienyl)phenyl]amino}carbonyl)phenyl]-N,N′-diisoxazol-3-ylmalonamide;

2-[4-({[2-amino-5-(2-thienyl)phenyl]amino}carbonyl)phenyl]-N-methyl-N-phenylmalonamide;

2-[4-({[2-amino-5-(2-thienyl)phenyl]amino}carbonyl)phenyl]-N-ethyl-N-phenylmalonamide;

2-[4-({[2-amino-5-(2-thienyl)phenyl]amino}carbonyl)phenyl]-N,N′-diphenylmalonamide;

2-[4-({[2-amino-5-(2-thienyl)phenyl]amino}carbonyl)benzyl]-N,N′-bis(4-fluorobenzyl)malonamide;

2-[4-({[2-amino-5-(2-thienyl)phenyl]amino}carbonyl)benzyl]-N,N′-dibenzylmalonamide;

2-[4-({[2-amino-5-(2-thienyl)phenyl]amino}carbonyl)benzyl]-N,N′-diphenylmalonamide;

2-(5-{[(2-amino-5-thien-2-ylphenyl)amino]carbonyl}thien-3-yl)-N,N′-diphenylmalonamide;

2-[4-({[2-amino-5-(3-thienyl)phenyl]amino}carbonyl)phenyl]malonamide;

2-[4-({[2-amino-5-(3-thienyl)phenyl]amino}carbonyl)phenyl]-N-methyl-N-phenylmalonamide;

2-[4-({[2-amino-5-(3-thienyl)phenyl]amino}carbonyl)phenyl]-N-ethyl-N-phenylmalonamide;

2-(4-{[(4-amino-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}phenyl)-N,N′-diphenylmalonamide;

2-(4-{[(4-amino-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}phenyl)-N-phenylmalonamide;

2-[4-({[4-amino-1-(3-chlorophenyl)-1H-pyrazol-3-yl]amino}carbonyl)phenyl]-N-phenylmalonamide;

2-(4-{[(4-amino-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}benzyl)-N,N′-diphenylmalonamide;

2-(4-{[(4-amino-3-methylisoxazol-5-yl)amino]carbonyl}phenyl)-N,N′-diphenylmalonamide;

or a stereoisomer or pharmaceutically acceptable salt thereof.

16. A pharmaceutical composition comprising a pharmaceutically effective amount of the compound according to claim 1 , and a pharmaceutically acceptable carrier.

17. A method of treating cancer comprising the step of administering to a subject a therapeutically effective amount of the compound of claim 1 .