Pancreatic Cancer Genes
The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
1 . A method of diagnosing cancer in a patient comprising comparing the amount of a polypeptide in a patient sample and in a normal sample, wherein said polypeptide comprises the polypeptide encoded by SEQ ID NO: 12, or a naturally occurring variant of SEQ ID NO: 12, wherein said naturally occurring variant hybridizes to SEQ ID NO: 12 under conditions including a wash in 2×SCC, 0.1% SDS at 50° C. for 20 minutes; and wherein a patient sample containing less of said polypeptide than the normal sample is identified as cancerous.
2 . A method of diagnosing cancer in a patient comprising determining the amount of a polypeptide in a patient sample and in a normal sample, wherein said first polypeptide is encoded by a polynucleotide selected from the group consisting of SEQ ID NOS: 1, 3-4, 6-11, and 13-14; determining the amount of a second polypeptide in the patient sample and in the normal sample, wherein said second polypeptide is encoded by SEQ ID NO: 12; and comparing the determined amounts; wherein a patient sample which contains less of the second polypeptide than the normal sample and which contains substantially the same amount of the first polypeptide, as compared to the normal sample, is identified as cancerous.
3 . The method of claim 1 or 2 , wherein the cancer is pancreatic cancer.
4 . The method of claim 1 or 2 , wherein the patient sample and the normal sample comprise pancreatic cells.