IP Library › Granted Patent US 7,947,842
Granted Patent B2
US 7,947,842 · App. 11/950,555 · Granted May 24, 2011

Hydrates of alkaline-earth salts of irbesartan and the preparation thereof

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Quick Facts
Patent No.
US 7,947,842
App. No.
11/950,555
Granted
May 24, 2011
Kind
B2
Abstract

The invention relates to hydrates of pharmaceutically acceptable alkaline-earth salts of irbesartan and to their preparation in an aqueous medium.

Claims (9)

1. A compound which is a hydrate of a pharmaceutically acceptable alkaline earth metal salt of irbesartan.

2. The compound according to claim 1 , selected from a hydrate of the calcium salt of irbesartan, and a hydrate of the magnesium salt of irbesartan.

3. The compound according to claim 2 , which is a tetrahydrate of the calcium salt of irbesartan.

4. The compound according to claim 2 , which is a tetrahydrate of the magnesium salt of irbesartan.

5. The compound according to claim 3 , wherein the compound is in a crystalline form.

6. The compound according to claim 4 , wherein the compound is in a crystalline form.

7. A process for the preparation of an irbesartan salt hydrate according to claim 1 , comprising:

preparing a sodium salt of irbesartan in aqueous solution; and then

displacing the sodium salt of irbesartan by the desired alkaline earth metal salt in aqueous medium.

Assignments (2)
CHANGE OF NAME Recorded Jun 20, 2012
From: SANOFI-AVENTIS
To: SANOFI
Reel/Frame 028413/0927 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2008
From: AULOMBARD, ALAIN; MERCEY, PHILIPPE
To: SANOFI-AVENTIS
Reel/Frame 020358/0162 →