Methods of treating pulmonary disease using acetazolamide and structurally related derivatives
The present invention is directed to a method of treating a subject for a pulmonary disease by administering a therapeutically effective amount of a compound of the formula: wherein R 1 , R 2 or R 3 are each independently a C 1 to C 6 alkyl, a halogen, a sulfate, or a phosphate. The pulmonary disease in the subject can be hypoxic pulmonary vasoconstriction, pulmonary edema, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, cystic fibrosis, interstitial fibrosis, high altitude residence, sleep apnea syndrome, atrial septal defects, and pulmonary diseases associated with other conditions. If this same compound is modified so that R 1 , R 2 or R 3 each independently is a C 1 to C 6 alkyl and the compound is not a carbonic acid inhibitor, it can be administered to a subject to block hypoxic pulmonary vasoconstriction and/or prevent high altitude pulmonary edema. Additional aspects of the present invention include an inhalable composition comprising the compound of the above formula without modification and an inhalable carrier, as well as the above modified compound.
1. A method of treating a subject for a pulmonary disease selected from the group consisting of hypoxic pulmonary vasoconstriction, pulmonary edema, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, cystic fibrosis, interstitial fibrosis, high altitude residence, sleep apnea syndrome, and atrial septal defects, said method comprising:
administering to the subject a compound of the formula:
where R 1 and R 3 are each methyl and R 2 is hydrogen;
wherein the compound is administered orally, parenterally, subcutaneously, intravenously, intramuscularly, intraperitoneally, by intranasal instillation, by inhalation, and/or by application to mucous membranes of the nose, throat, and/or bronchial tubes;
under conditions effective to treat the pulmonary disease in the subject.
2. The method of claim 1 , wherein the subject is human.