Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same

1. A compound according to formula (I):

wherein:

R1 is tert-butyl and Ar2 is 2,6-dichlorophenyl; or

R1 is tert-butyl and Ar2 is 2-bromo-6-chlorophenyl; or

R1 is ethyl and Ar2 is 2,6-dichlorophenyl; or

R1 is tert-butyl and Ar2 is 2,6-dibromophenyl; or

R1 is ethyl and Ar2 is 2,6-dibromophenyl; or

R1 is phenyl and Ar2 is 2,6-dichlorophenyl; or

R1 is tert-butyl and Ar2 is 3,5-dimethoxyphenyl; or

R1 is tert-butyl and Ar2 is phenyl; or

R1 is tert-butyl and Ar2 is 2,6-dimethylphenyl; or

R1 is tert-butyl and Ar2 is 2,6-difluorophenyl; or

R1 is isopropyl and Ar2 is 2,6-dichlorophenyl;

or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 , which is:

or a pharmaceutically acceptable salt thereof.

3. A compound selected from the group consisting of:

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea;

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-ethylurea;

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea;

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-ethylurea;

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-phenylurea;

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea;

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea;

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea;

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-difluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea; and

N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1-methylethyl)urea;

or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof; and at least one pharmaceutically acceptable excipient.

5. A pharmaceutical composition comprising a compound according to claim 3 or a pharmaceutically acceptable salt thereof; and at least one pharmaceutically acceptable excipient.

6. A pharmaceutical composition comprising a compound according to claim 2 or a pharmaceutically acceptable salt thereof; and at least one pharmaceutically acceptable excipient.