IP Library › Granted Patent US 7,700,113
Granted Patent B2
US 7,700,113 · App. 11/975,522 · Granted Apr 20, 2010

Inhibiting breast cancer cell growth by administering an intracellular domain of NOTCH2

Assignee: Maine Medical Research Institute, a division of Maine Medical Center
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Quick Facts
Patent No.
US 7,700,113
App. No.
11/975,522
Granted
Apr 20, 2010
Kind
B2
Abstract

The present invention relates to the ability of constitutively active Notch 2 to function as an inhibitor of breast cancer. The invention provides methods and compositions for inhibiting breast cancer cells by using hNotch2ICD polypeptides.

Claims (2)

1. A method of inhibiting the growth of a breast cancer cell in a human having breast cancer, said method comprising administering to said human an isolated polypeptide consisting of the intracellular domain of human Notch 2 (hNotch2ICD) as set forth in SEQ ID NO: 3, wherein said polypeptide inhibits the growth of said breast cancer cell.

2. The method of claim 1 , wherein said polypeptide further comprises a detectable label.

Assignments (2)
CONFIRMATORY LICENSE Recorded Sep 18, 2012
From: MAINE MEDICAL CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 029000/0844 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 17, 2008
From: LIAW, LUCY, MS.
To: MAINE MEDICAL RESEARCH INSTITUTE, A DIVISION OF MAINE MEDICAL CENTER
Reel/Frame 020377/0404 →
Continuity (2)
Provisional Application 6085274900 · Oct 19, 2006
Related Publication 20080112940A1 · May 15, 2008