Granted Patent
B2
US 8,748,121 · App. 11/976,316 · Granted Jun 10, 2014
GSH adducts and uses thereof
Inventors:
Ian Blair (Wynnewood, PA); Clementina Mesaros (Philadelphia, PA); Wenying Jian (Princeton, NJ); Seon Hwa Lee (Aoba-ku, JP); Tomoyuki Oe (Aoba-ku, JP)
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Abstract
The invention relates to biomarkers of oxidative stress and their use. Specifically, the invention relates to thiadiazabicyclo-4-oxo-2(E)-nonenal-Glutathione adduct as a biomarker of oxidative stress and its diagnostic use.
Claims (1)
1. A method of detecting a level of oxidative stress in a cell comprising the steps of: quantifying the amount of Thiadiazabicyclo-4-oxo-2(E)-nonenal-Glutathione (TOG) in the cell; and comparing said amount to the level of Thiadiazabicyclo-4-oxo-2(E)-nonenal-Glutathione (TOG) in a predetermined standard.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Sep 26, 2014
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 033832/0150 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 26, 2008
From: BLAIR, IAN; MESAROS, CLEMENTINA; JIAN, WENYING; LEE, SEON HWA; OE, TOMOYUKI
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 021152/0599 →
Continuity (2)
Provisional Application
60853714
· Oct 23, 2006