Compositions comprising a ligand of Chemerin R
The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
1. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of LFPGQFAFS (SEQ ID NO: 92), IFPGQFAFS (SEQ ID NO: 93), FLPGQFAFS (SEQ ID NO: 94), YLPGQFAFS (SEQ ID NO: 95), YVPGQFAFS (SEQ ID NO: 96 and YFPGQFAFD-CONH2 (SEQ ID NO: 97), wherein the polypeptide binds specifically to a ChemerinR polypeptide of SEQ ID NO: 2.
2. A composition comprising the polypeptide of claim 1 .