Magnet assembly
View Patent ↗A magnet assembly for use in carrying out nuclear magnetic resonance experiments on a body or sample. The assembly comprises a set of superconducting coils within a cryostat, located about a bore, and arranged to generate a substantially uniform magnetic field in a primary working volume within the bore, and to generate a substantially uniform magnetic field in a secondary working volume within the coil structure and separate from the bore. At least part of a hyperpolarisation system intersects the at least one secondary working volume so as to hold a sample to be hyperpolarised in the secondary working volume.
1. A magnet assembly for use in carrying out nuclear magnetic resonance experiments on a body or sample, the assembly comprising a set of superconducting coils within a cryostat, located about a bore, and arranged to generate a substantially uniform magnetic field in a primary working volume within the bore, and to generate a substantially uniform magnetic field in a secondary working volume within the coil structure and separate from the bore; and at least part of a hyperpolarisation system intersecting the at least one secondary working volume so as to hold a sample to be hyperpolarised in the secondary working volume.
2. An assembly according to claim 1 , wherein the magnetic field generated in the primary working volume is stronger than the magnetic field generated in the secondary working volume.
3. An assembly according to claim 1 , wherein the uniformity of the magnetic field in the primary working volume is better than 10 ppm over a 10 mm diameter×10 mm long cylindrical volume.
4. An assembly according to claim 1 , wherein the set of superconducting coils define an actively shielded magnet having a main magnet around which is located a shield magnet, the secondary working volume being located between the main and shield magnets.
5. An assembly according to claim 1 , wherein the secondary working volume is located between an axially spaced pair of the coils.
6. An assembly according to claim 1 , wherein the secondary working volume is toroidal.
7. An assembly according to claim 1 , comprising more than one hyperpolarisation system, the hyperpolarisation systems being located at respective, preferably annually, spaced positions in the secondary working volume.
8. An assembly according to claim 1 , wherein the uniformity of the secondary working volume is in the range 10-500 ppm.
9. An assembly according to claim 8 , comprising more than one hyperpolarisation system, the hyperpolarisation system being located at respective, preferably annually, spaced positions in the secondary working volume, wherein the uniformity is in the range 10-500 ppm over the toroidal region with a 10-20 mm diameter.
10. An assembly according to claim 1 , further comprising a sample transport system extending between the secondary and primary working volumes.
11. An assembly according to claim 10 , wherein the sample transport system comprises a conduit through which a hyperpolarised sample is moved in use from the secondary to the primary working volume.
12. An assembly according to claim 11 , wherein a melted or dissolved sample is moved by pressurised gas through the conduit.
13. An assembly according to claim 1 , wherein the hyperpolarisation system is adapted to carry out one of dynamic nuclear polarisation, parahydrogen induced polarisation, “brute force” polarization, and optically induced polarisation.
14. An assembly according to claim 1 , wherein the primary and secondary working volumes are located such that a sample can be hyperpolarised in the secondary working volume while a nuclear magnetic resonance experiment is performed in the primary working volume.
15. An assembly according to claim 1 , wherein the part of the hyperpolarisation system which intersects the secondary working volume is a polarisation cell.
16. An assembly according to claim 15 , wherein the polarisation cell includes a microwave cavity.
17. An assembly according to claim 15 , wherein the polarisation cell includes an insert cryostat suitable for cooling the sample.
18. An assembly according to claim 1 , further comprising a NMR probe extending into the primary working volume.
19. An assembly according to claim 1 , wherein the bore is sized to accommodate all or part of a human or animal body.
20. A method of hyperpolarising samples using an assembly according to claim 1 , comprising more than one hyperpolarisation system, the hyperpolarisation systems being located at respective, preferably annually, spaced positions in the secondary working volume, wherein a plurality of samples are hyperpolarised by respective hyperpolarisation systems and then transferred sequentially to the primary working volume.
21. A method according to claim 20 , further comprising supplying a new sample to each hyperpolarisation system once a previous sample has been supplied from that system to the primary working volume.
22. An assembly according to claim 1 , wherein the uniformity of the magnetic field in the primary working volume is preferably 0.1 ppm over a 10 mm diameter×10 mm long cylindrical volume.