Biocompatible Antimicrobial Filament Material
The invention provides a biocompatible filament material having an antimicrobial finish, in particular in the form of a surficial layer, the finish comprising polyhexamethylenebiguanide (PHMB) as a nonspecifically antimicrobially active component, and also a process for producing the filament material, comprising the steps of: producing an active solution from the nonspecifically antimicrobially active component PHMB and a solvent, transferring PHMB from the active solution onto and/or into the filament material, and drying the filament material comprising the transferred PHMB.
1 . A biocompatible filament material having an antimicrobial finish, in particular in the form of a surficial layer, the finish comprising polyhexamethylenebiguanide (PHMB) as a nonspecifically antimicrobially active component.
2 . The filament material according to claim 1 , characterized in that it is mono- or multifil, especially multifil.
3 . The filament material according to claim 1 , characterized in that it is in the form of a braid, a formed-loop knit or a drawn-loop knit, in particular in the form of a formed-loop knit.
4 . The filament material according to claim 1 , characterized in that it is in the form of a textile sheetlike construction, in particular as a tape or mesh, preferably as a hernial mesh.
5 . The filament material according to claim 1 , characterized in that it is in the form of suture.
6 . The filament material according to claim 1 , characterized in that the nonspecifically antimicrobially active component PHMB is present on the surface.
7 . The filament material according to claim 1 , characterized in that it is antimicrobially active for at least 7 days, preferably for 10 to 14 days.
8 . The filament material according to claim 1 , characterized in that it comprises and preferably consists of an absorbable polymer, in particular a hydrolyzable polymer.
9 . The filament material according to claim 8 , characterized in that the polymer comprises lactide and/or glycolide polymer, preferably glycolide polymer.
10 . The filament material according to claim 1 , characterized in that the PHMB content on the surface of the coated material is μg/cm2
11 . The filament material according to claim 1 , characterized in that the PHMB content in the antimicrobially finished filament material is 2-3000 ppm.
12 . The filament material according to claim 1 , characterized in that material has a surface coating other than the antimicrobial finish.
13 . The filament material according to claim 12 , characterized in that the fraction of coating material in terms of total material (filament material including coating material) is 0.1-5% by weight.
14 . The filament material according to claim 12 , characterized in that the coating material comprises at least one selected from the group consisting of polyethylene, polyester, silicone and polyurethane.
15 . The filament material according to claim 1 , characterized in that the product is free of any coating.
16 . A process for producing a biocompatible filament material according to claim 1 , comprising the steps of:
producing an active solution from the nonspecifically antimicrobially active component PHMB and a solvent,
transferring PHMB from the active solution onto and/or into the filament material, and
drying the filament material comprising the transferred PHMB.
17 . The process according to claim 16 , characterized in that at least one organic solvent, especially an alcohol, ketone and/or an aromatic solvent, is used.
18 . The process according to claim 16 , characterized in that water is used as solvent.
19 . The process according to claim 16 , characterized in that the concentration of PHMB in the active solution is in the range from 0.1% to 20% by weight and preferably in the range from 0.3% to 8% by weight.
20 . The process according to any claim 16 , characterized in that the transferring is effected by dipping the filament material into the active solution.
21 . The process according to claim 16 , characterized in that the transferring is effected by spraying the active solution onto the filament material.
22 . The process according to claim 16 , characterized in that the coating material is dissolved together with the antimicrobially active component PHMB and subsequently applied to the filament material.
23 . The process according to claim 16 , characterized in that the concentration of coating material in the active solution is in the range from 0.5% to 5% by weight and preferably in the range from 1% to 3.5% by weight.
24 . The process according to claim 16 , characterized in that the filament material is surface treated, in particular by sputtering or by plasma activation, in particular by plasma activation, before the active solution is applied.
25 . Provision of the biocompatible filament material according to claim 1 for use in relation to the human or animal organism, especially in relation to wound closure and/or hernias.