IP Library › Granted Patent US 7,576,209
Granted Patent B2
US 7,576,209 · App. 11/999,234 · Granted Aug 18, 2009

Inhibitors of Akt activity

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Quick Facts
Patent No.
US 7,576,209
App. No.
11/999,234
Granted
Aug 18, 2009
Kind
B2
Abstract

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

Claims (3)

1. A compound which is:

8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3(2H)-one;

or a pharmaceutically acceptable salt thereof.

Assignments (5)
MERGER Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →
CHANGE OF NAME Recorded Aug 29, 2012
From: SCHERING CORPORATION
To: MERCK SHARP & DOHME CORP.
Reel/Frame 028866/0511 →
MERGER Recorded Aug 27, 2012
From: MERCK SHARP & DOHME CORP.
To: SCHERING CORPORATION
Reel/Frame 028850/0515 →
CHANGE OF NAME Recorded Jan 29, 2010
From: MERCK & CO., INC.
To: MERCK SHARP & DOHME CORP.
Reel/Frame 023870/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 3, 2008
From: KELLY, MICHAEL J., III; LAYTON, MARK E.; SANDERSON, PHILIP E.
To: MERCK & CO., INC.
Reel/Frame 020761/0289 →