Compounds having β

1. A compound of formula I:

wherein

one of G 1 and G 2 represents NH and the other represents S, NH, O or CH 2 ;

W represents O or NW a ; where W a is hydrogen or (1-4C)alkyl;

each R 1 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR 1a , —C(O)OR 1b , —SR 1c , —S(O)R 1d , —S(O) 2 R 1e and —NR 1f R 1g ; where each of R 1a , R 1b , R 1c , R 1d , R 1e , R 1f and R 1g ; is independently hydrogen, (1-4C)alkyl or phenyl-(1-4C)alkyl;

each R 2 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR 2a ,—C(O)OR 2b , —SR 2c , —S(O)R 2d , —S(O) 2 R 2e and —NR 2f R 2g ; where each of R 2a , R 2b , R 2c , R 2d , R 2e , R 2f and R 2g is independently hydrogen, (1-4C)alkyl or phenyl-(1-4C)alkyl;

each R 3 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR 3a , —C(O)OR 3b , —SR 3c , —S(O)R 3d , —S(O) 2 R 3e and —NR 3f R 3g ; or two R 3 groups are joined to form (1-3C)alkylene, (2-3C)alkenylene or oxiran-2,3-diyl; where each of R 3a , R 3b , R 3c , R 3d , R 3e , R 3f and R 3g is independently hydrogen or (1-4C)alkyl;

R 4 represents a divalent hydrocarbon group containing from 4 to 28 carbon atoms and optionally containing from 1 to 10 heteroatoms selected independently from halo, oxygen, nitrogen and sulfur, provided that the number of contiguous atoms in the shortest chain between the two nitrogen atoms to which R 4 is attached is in the range of from 4 to 16;

R 5 represents hydrogen or (1-4C)alkyl;

R 6 represents hydrogen or hydroxyl;

each R 7a and R 7b is independently selected from hydrogen, (1-4C)alkyl, hydroxy and fluoro;

a is 0 or an integer of from 1 to 3;

b is 0 or an integer of from 1 to 3;

c is 0 or an integer of from 1 to 4;

d is 0 or an integer of from 1 to 5; and

m is 0 or an integer of from 1 to 3;

or a pharmaceutically acceptable salt or stereoisomer thereof.

2. A compound of formula I:

wherein G 1 represents S, NH, O or CH 2 and G 2 represents NH;

W represents O or NW a ; where W a is hydrogen or (1-4C)alkyl;

each R 1 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR 1a , —C(O)OR 1b , —SR 1c , —S(O)R 1d , —S(O) 2 R 1e and —NR 1f R 1g ; where each of R 1a , R 1b , R 1c , R 1d , R 1e , R 1f and R 1g is independently hydrogen, (1-4C)alkyl or phenyl-(1-4C)alkyl;

each R 2 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR 2a , —C(O)OR 2b , —SR 2c , —S(O)R 2d , —S(O) 2 R 2e and —NR 2f R 2g ; where each of R 2a , R 2b , R 2c , R 2d , R 2e , R 2f and R 2g is independently hydrogen, (1-4C)alkyl or phenyl-(1-4C)alkyl;

each R 3 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR 3a ,—C(O)OR 3b , —SR 3c , —S(O)R 3d , —S(O) 2 R 3e and —NR 3f R 3g ; or two R 3 groups are joined to form (1-3C)alkylene, (2-3C)alkenylene or oxiran-2,3-diyl where each of R 3a , R 3b , R 3c , R 3d , R 3e , R 3f and R 3g is independently hydrogen or (1-4C)alkyl;

R 4 represents a divalent hydrocarbon group containing from 4 to 28 carbon atoms and optionally containing from 1 to 10 heteroatoms selected independently from halo, oxygen, nitrogen and sulfur, provided that the number of contiguous atoms in the shortest chain between the two nitrogen atoms to which R 4 is attached is in the range of from 4 to 16;

R 5 represents hydrogen or (1-4C)alkyl;

R 6 represents hydrogen or hydroxyl;

each R 7a and R 7b is independently selected from hydrogen, (1-4C)alkyl, hydroxy and fluoro;

a is 0 or an integer of from 1 to 3;

b is 0 or an integer of from 1 to 3;

c is 0 or an integer of from 1 to 4;

d is 0 or an integer of from 1 to 5; and

m is 0 or an integer of from 1 to 3;

or a pharmaceutically acceptable salt or stereoisomer thereof.

3. The compound of claim 1 , wherein W is O.

4. The compound of claim 1 , wherein a, b, and c are each 0, and R 5 is hydrogen.

5. The compound of claim 1 , wherein d is 0.

6. The compound of claim 1 , wherein d is 1; and

R 7a and R 7b are both hydrogen.

7. The compound of claim 1 , wherein m is 2.

8. The compound of claim 1 , wherein G 1 is S and G 2 is NH.

9. The compound of claim 1 , wherein R 6 is hydrogen.

10. The compound of claim 1 , wherein R 6 is hydroxy.

11. The compound of claim 1 , wherein R 4 is a divalent group of the formula:

—(R 4a ) d -(A 1 ) e -(R 4b ) f -Q-(R 4c ) g -(A 2 ) h -(R 4d ) i —

wherein

d, e, f, g, h and i are each independently selected from 0 and 1;

R 4a , R 4b , R 4c and R 4d are each independently selected from (1-10C)alkylene, (2-10C)alkenylene and (2-10C)alkynylene, wherein each alkylene, alkenylene or alkynylene group is unsubstituted or substituted with from 1 to 5 substituents independently selected from (1-4C)alkyl, fluoro, hydroxy, phenyl and phenyl-(1-4C)alkyl;

A 1 and A 2 are each independently selected from (3-7C)cycloalkylene, (6-10C)arylene, —O-(6-10C)arylene-O—, (2-9C)heteroarylene, —O—(2-9C)heteroarylene, (2-9C)heteroarylene-O—and (3-6C)heterocyclene, wherein each cycloalkylene is unsubstituted or substituted with from 1 to 4 substituents selected independently from (1-4C)alkyl, and each arylene, heteroarylene or heterocyclene group is unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, (1-4C)alkyl, (1-4C)alkoxy, —S-(1-4C)alkyl, -S(O)-(1-4C)alkyl, —S(O) 2 -(1-4C)alkyl, —C(O)O(1-4C)alkyl, carboxy, cyano, hydroxy, nitro, trifluoromethyl and trifluoromethoxy;

Q is selected from a bond, —O—, —C(O)O—, —OC(O)—, —S—, —S(O)—, —S(O) 2 , —N(Q a )C(O)—, —C(O)N(Q b )-, —N(Q c )S(O) 2 —, —S(O) 2 N(Q d )-, —N(Q e )C(O)N(Q f )-, —N(Q g )S(O) 2 N(Q h )-, —OC(O)N(Q i )-, —N(Q j )C(O)O—and —N(Q k );

Q a , Q b , Q c , Q d , Q e , Q f , Q g , Q h , Q i , Q j and Q k are each independently selected from hydrogen, (1-6C)alkyl, A 3 and (1-4C)alkylene-A 4 , wherein the alkyl group is unsubstituted or substituted with from 1 to 3 substituents independently selected from fluoro, hydroxy and (1-4C)alkoxy; or together with the nitrogen atom and the group R 4b or R 4c to which they are attached, form a 4-6 membered azacycloalkylene group;

A 3 and A 4 are each independently selected from (3-6C)cycloalkyl, (6-10C)aryl, (2-9C)heteroaryl and (3-6C)heterocyclyl, wherein each cycloalkyl is unsubstituted or substituted with from 1 to 4 substituents selected independently from (1-4C)alkyl and each aryl, heteroaryl or heterocyclyl group is unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, (1-4C)alkyl and (1-4C)alkoxy.

12. The compound of claim 11 , wherein R 4 is a divalent group of the formula: —(R 4a ) d - where R 4a is (4-10C)alkylene.

13. The compound of claim 12 , wherein R 4 is —(CH 2 ) 4 —, —(CH 2 ) 5 —, —(CH 2 ) 6 —, —(CH 2 ) 7 —, —(CH 2 ) 8 —, —(CH 2 ) 9 —, or —(CH 2 ) 10 —.

14. The compound of claim 11 , wherein R 4 is a divalent group of the formula:

—(R 4a ) d -(A 2 ) h -(R 4d ) i —

where R 4a is (1-10C)alkylene; A 2 is (6-10C)arylene or (2-9C)heteroarylene; and

R 4d is (1-10C)alkylene.

15. The compound of claim 11 , wherein R 4 is a divalent group of the formula:

—(R 4a ) d -(A 2 ) h -(R 4d ) i —

where Q is —OR—or-N(Q k )-; Q k is hydrogen or (1-3C)alkyl; R 4a is (1-10C)alkylene; A 2 is (6-10C)arylene or (2-9C)heteroarylene; and R 4d is (1-10C)alkylene.

16. The compound of claim 11 , wherein Q is —N(Q a )C(O)— or —C(O)N(Q b )-.

17. The compound of claim 2 , wherein W is O.

18. The compound of claim 2 , wherein a, b, and c are each 0, and R 5 is hydrogen.

19. The compound of claim 2 , wherein d is 0.

20. The compound of claim 2 , wherein d is 1; and

R 7a and R 7b are both hydrogen.

21. The compound of claim 2 , wherein m is 2.

22. The compound of claim 2 , wherein G l is S and G 2 is NH.

23. The compound of claim 2 , wherein R 6 is hydrogen.

24. The compound of claim 2 , wherein R 6 is hydroxy.

25. The compound of claim 2 , wherein R 4 is a divalent group of the formula:

—(R 4a ) d -(A 1 ) e -(R 4b ) f -Q-(R 4c ) g -(A 2 ) h -(R 4d ) i —

wherein

d, e, f, g, h and i are each independently selected from 0 and 1;

R 4a , R 4b , R 4c and R d are each independently selected from (1-10C)alkylene, (2-10C)alkenylene and (2-10C)alkynylene, wherein each alkylene, alkenylene or alkynylene group is unsubstituted or substituted with from 1 to 5 substituents independently selected from (1-4C)alkyl, fluoro, hydroxy, phenyl and phenyl-(1-4C)alkyl;

A l and A 2 are each independently selected from (3-7C)cycloalkylene, (6-1 OC)arylene, —O—(6-10C)arylene, (6-10C)arylene—O—(2-9C)heteroarylene, —O—(2-9C)heteroarylene, (2-9C)heteroarylene-O—and (3-6C)heterocyclene, wherein each cycloalkylene is unsubstituted or substituted with from 1 to 4 substituents selected independently from (1-4C)alkyl, and each arylene, heteroarylene or heterocyclene group is unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, (1-4C)alkyl, (1-4C)alkoxy, —S—(1-4C)alkyl, —S(O)—(1-4C)alkyl, —S(O) 2 —(1-4C)alkyl, —C(O)O(1-4C)alkyl, carboxy, cyano, hydroxy, nitro, trifluoromethyl and trifluoromethoxy;

Q is selected from a bond, —O—,—C(O)O—, —OC(O)—, —S—, —S(O)—, —S(O) 2 —, —N(Q a )C(O)—, —C(O)N(Q b )-, —N(Q c )S(O) 2 —, —S(O) 2 N(Q d )-, —N(Q e )C(O)N(Q f )-, —N(Q g )S(O) 2 N(Q h )-, —OC(O)N(Q i )-, —N(Q j )C(O)O—and —N(Q k );

Q a , Q b , Q c , Q d , Q e , Q f , Q g , Q h , Q i , Q j and Q k are each independently selected from hydrogen, (1-6C)alkyl, A 3 and (1-4C)alkylene-A 4 wherein the alkyl group is unsubstituted or substituted with from 1 to 3 substituents independently selected from fluoro, hydroxy and (1-4C)alkoxy; or together with the nitrogen atom and the group R 4b or R 4c to which they are attached, form a 4-6 membered azacycloalkylene group;

A 3 and A 4 are each independently selected from (3-6C)cycloalkyl, (6-10C)aryl, (2-9C)heteroaryl and (3-6C)heterocyclyl, wherein each cycloalkyl is unsubstituted or substituted with from 1 to 4 substituents selected independently from (1-4C)alkyl and each aryl, heteroaryl or heterocyclyl group is unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, (1-4C)alkyl and (1-4C)alkoxy.

26. The compound of claim 25 , wherein R 4 is a divalent group of the formula: —(R 4a ) d — where R 4a is (4-10C)alkylene.

27. The compound of claim 26 , wherein R 4 is —(CH 2 ) 4 —, —(CH 2 ) 5 —, —(CH 2 ) 6 —, —(CH 2 ) 7 —, —(CH 2 ) 8 —, —(CH 2 ) 9 —, or —(CH 2 ) 10 —.

28. The compound of claim 25 , wherein R 4 is a divalent group of the formula:

—(R 4a ) d -(A 2 ) h -(R 4d ) i —

where R 4a is (1-10C)alkylene; A 2 is (6-10C)arylene or (2-9C)heteroarylene; and R 4d is (1-10C)alkylene.

29. The compound of claim 25 , wherein R 4 is a divalent group of the formula:

—(R 4a ) d -Q-(A 2 ) h -(R 4d ) i —

where Q is —O— or —N(Q k )-; Q k is hydrogen or (1-3C)alkyl; R 4a is (1-10C)alkylene; A 2 is (6-10C)arylene or (2-9C)heteroarylene; and R 4d is (1-10C)alkylene.

30. The compound of claim 25 , wherein Q is —N(Q a )C(O)— or —C(O)N(Q b )-.