Certain chemical entities, compositions, and methods
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
1 - 46 . (canceled)
47 . A method for the treatment of a solid tumor comprising administering to a subject in need thereof an effective amount of at least one compound chosen from N-(2-(2-dimethylamino-acetylamino)-1-{4-[8-(1-hydroxy-ethyl)-imidazo[1,2-a]pyridin-2-yl]-benzyl}-ethyl)-3-chloro-4-isopropoxy-benzamide and pharmaceutically acceptable salts thereof.
48 . A method for the treatment of a solid tumor comprising administering to a subject in need thereof an effective amount of at least one compound chosen from N-{1-[4-(8-(1-hydroxy-ethyl)-imidazo[1,2-a]pyridin-2-yl)-benzyl]-3-hydroxy-propyl}-3-chloro-4-isopropoxy-benzamide and pharmaceutically acceptable salts thereof.
49 . A method for the treatment of a solid tumor comprising administering to a subject in need thereof an effective amount of at least one compound chosen from N-(2-(2-dimethylamino-acetylamino)-1-{4-[8-methyl-imidazo[1,2-a]pyridin-2-yl]-benzyl}-ethyl)-3-chloro-4-isopropoxy-benzamide and pharmaceutically acceptable salts thereof.
50 . A method for the treatment of a solid tumor comprising administering to a subject in need thereof an effective amount of at least one compound chosen from N-(2-(2-amino-2-methyl-propionylamino)-1-{4-[8-methyl-imidazo[1,2-a]pyridin-2-yl]-benzyl}-ethyl)-3-chloro-4-isopropoxy-benzamide and pharmaceutically acceptable salts thereof.
51 . A method for the treatment of a solid tumor comprising administering to a subject in need thereof an effective amount of at least one compound chosen from 3-chloro-N-((2S)-1-(2-(dimethylamino)acetamido)-3-(4-(8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-4-isopropoxybenzamide
and pharmaceutically acceptable salts thereof.
52 . A method for the treatment of a solid tumor comprising administering to a subject in need thereof an effective amount of at least one compound chosen from (S)-3-chloro-N-(1-(2-(dimethylamino)acetamido)-3-(4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-4-isopropoxybenzamide
and pharmaceutically acceptable salts thereof.
53 . A method for the treatment of a solid tumor comprising administering to a subject in need thereof an effective amount of at least one compound chosen from (S)—N-(1-(2-amino-2-methylpropanamido)-3-(4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzamide
and pharmaceutically acceptable salts thereof.