Topical anesthetic for rapid local anesthesia
A topical anesthetic for rapid local anesthesia is provided. The topical anesthetic includes an anesthetic, volatile and non-volatile solvents, and a thickener. In addition, a method is taught for applying the topical anesthetic to the face of a patient without occlusion. The anesthetic is applied topically to an area for injection such that the dermatological procedure (cosmetic injections) can be performed in fifteen minutes.
1. A topical anesthetic for rapid local anesthesia, comprising:
up to four weight percent of an anesthetic agent;
from sixty to eighty five weight percent isopropyl alcohol;
between two and six weight percent propylene glycol;
from two to six weight percent oleyl alcohol;
up to 25 weight percent of volatile silicone; and
hydroxypropylcellulose.
2. A topical anesthetic composition for delivery of rapid local anesthesia comprising:
(a) a topical anesthetic;
(b) a solvent system comprising:
(i) a first non-volatile solvent comprising 2- 6% by weight of a fatty alcohol or acid selected from the group consisting of (1) C 10 -C 14 saturated alcohols or their corresponding acids and (2) liquid-at-room temperature C 12 -C 22 mono- or poly-unsaturated or branched alcohols or their corresponding acids;
(ii) a second non-volatile solvent comprising 2- 6% by weight of an alcohol selected from the group consisting of propylene glycol and butane diols with adjacent OH groups; and
(iii) a volatile short chain alcohol;
wherein the composition penetrates intact skin without occlusion to effectuate maximum local anesthetic affect within 15 to 20 minutes.
3. The topical anesthetic composition of claim 2 , wherein said anesthetic is present in amounts of about 4 to about 8 percent by weight.
4. The topical anesthetic composition of claim 3 , wherein said anesthetic comprises lidocaine.
5. The topical anesthetic composition of claim 2 , wherein said anesthetic is selected from the group consisting of articaine, bupivacaine, chloroprocaine, etiodocaine, levobupivacaine, lidocaine, mepivacaine, prilocaine, procaine and tetracaine.
6. The topical anesthetic composition of claim 2 , wherein the first non-volatile solvent comprises oleyl alcohol.
7. The topical anesthetic composition of claim 2 , wherein the short chain alcohol comprises isopropyl alcohol.
8. The topical anesthetic composition of claim 2 , further comprising a volatile silicone.
9. The topical anesthetic composition of claim 2 , further comprising a thickener.
10. The topical anesthetic composition of claim 2 , wherein the composition is a gel.
11. A topical anesthetic composition for rapid delivery of a local anesthesia comprising:
(a) a topical anesthetic comprising lidocaine;
(b) a solvent system comprising:
(i) a first non-volatile solvent comprising 2- 6% by weight of a fatty alcohol comprising oleyl alcohol;
(ii) a second non-volatile solvent comprising 2- 6% by weight of an alcohol comprising propylene glycol; and
(iii) a volatile short chain solvent;
wherein the composition penetrates intact skin without occlusion to effectuate maximum local anesthetic effect within 15 to 20 minutes.
12. The topical anesthetic composition of claim 11 , wherein the short chain alcohol is isopropyl alcohol.
13. The topical anesthetic composition of claim 11 , further comprising a volatile silicone.
14. The topical anesthetic composition of claim 11 , further comprising a thickener.
15. The topical anesthetic composition of claim 14 , wherein said thickener is present in an amount sufficient to produce a gel.