Positive modulator of bone morphogenic protein-2
Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
1. A compound of Formula II:
wherein:
X is a peptide sequence selected from the group consisting of SEQ ID NOs: 7-14;
R 1 is hydrogen, such that the terminal group is —NH 2 ;
R 6 is an amino acid;
R 5 is is a trifunctional amino acid;
R 4 is NH 2 at the carboxyl terminal group;
Y is Ahx-Ahx-Ahx, wherein Ahx is 6-aminohexanoic acid; and
Z is a peptide sequence selected from group consisting of SEQ ID NO 3-6.