Internal 1,15-lactones of fluprostenol and related prostaglandin F
Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into ophthalmic solutions and topically applied for the treatment of the increased intraocular pressure caused by glaucoma and the reduction of ocular hypertension.
1. A compound of the general formula:
wherein X is CH 2 ;
wherein R 1 and R 2 are the same and are either H, CH 3 or F;
wherein R 9 is H, or C 1 -C 20 straight chain, saturated or unsaturated or branched acyl;
wherein R 11 is H, or C 1 -C 20 straight chain, saturated or unsaturated or branched acyl;
wherein ---- represents any combination of a single bond, or a cis or trans double bond;
wherein Z is Br, I, CF 3 , CH 3 , or C 1 -C 10 straight chain or branched alkyl; and
wherein Y is O, S, NH or CH 2 when R 1 is CH 3 and R 2 is CH 3 or when Z is selected to be Br, I or a C 1 -C 10 straight chain or branched alkyl;
wherein Y is CH 2 except when R 1 is CH 3 and R 2 is CH 3 or when Z is selected to be Br, I or a C 1 -C 10 straight chain or branched alkyl.
2. A compound of the general formula:
wherein X is CH 2 ;
wherein R 1 and R 2 are the same and are either H, CH 3 or F;
wherein R 9 is H, or C 1 -C 20 straight chain, saturated or unsaturated or branched acyl;
wherein R 11 is H, or C 1 -C 20 straight chain, saturated or unsaturated or branched acyl;
wherein ---- represents any combination of a single bond, or a cis or trans double bond;
wherein Z is H, CI, Br, I, CF 3 , CH 3 , or C 1 -C 10 straight chain or branched alkyl; and
wherein Y is S or NH.
3. The compound of claim 1 , wherein R 1 and R 2 are H.
4. The compound of claim 1 , wherein R 1 and R 2 are F.