Methods and compositions for promoting wound healing
Provided herein are compositions and methods that inhibit expression of Adam12 gene products, such as ADAM12 mRNA and/or ADAM12 polypeptides, as a therapeutic approach for the treatment of, or promotion of healing of, wounds.
1. A method of promoting healing of a chronic wound, comprising:
administering to the wound an amount of a selective ADAM12 inhibitory compound effective to promote healing of the wound,
in which the ADAM12 inhibitory compound inhibits expression of mRNA encoding ADAM12.
2. The method of claim 1 in which the ADAM12 inhibitory compound is an antisense oligonucleotide, an iRNA, an siRNA, or a nucleic acid encoding an antisense oligonucleotide, an iRNA or an siRNA.
3. The method of claim 1 or claim 2 in which the ADAM12 inhibitory compound is administered locally to the wound.
4. The method of claim 3 in which the ADAM12 inhibitory compound is included in a dressing that is applied topically to the wound.
5. The method of claim 3 in which the ADAM12 inhibitory compound is administered locally to the wound via injection.
6. The method of claim 2 in which the ADAM12 inhibitor compound is an antisense oligonucleotide.
7. The method of claim 2 in which the ADAM12 inhibitor compound is a siRNA.
8. A method of promoting healing of a chronic wound, comprising:
administering to the wound an amount of a selective ADAM12 inhibitory compound effective to promote healing of the wound,
in which the ADAM12 inhibitor compound is an antibody.
9. The method of claim 8 , wherein the antibody is administered locally to the wound.
10. The method of claim 9 , wherein the antibody is administered locally to the wound via injection.
11. The method of claim 8 , wherein the antibody is administered topically to the wound.
12. The method of claim 11 in which the antibody is included in a dressing that is applied topically to the wound.
13. The method of claim 1 or claim 8 , wherein the chronic wound is an arterial ulcer, a diabetic foot ulcer or a venous ulcer.