Nematode fatty acid desaturase-like sequences
Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
1. An isolated nucleic acid molecule comprising a nucleotide sequence encoding a polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:8 wherein the polypeptide has fatty acid desaturase activity.
2. The isolated nucleic acid molecule of claim 1 wherein the polypeptide comprises an amino acid sequence that is at least 98% identical to SEQ ID NO:8.
3. The isolated nucleic acid molecule of claim 1 wherein the polypeptide consists of an amino acid sequence that is at least 95% identical to SEQ ID NO: 8.
4. The isolated nucleic acid molecule of claim 1 wherein the polypeptide consists of an amino acid sequence that is at least 98% identical to SEQ ID NO:8.
5. An isolated nucleic acid molecule encoding a polypeptide comprising SEQ ID NO:8.
6. The isolated nucleic acid molecule of claim 5 wherein the polypeptide consists of SEQ ID NO:8.
7. A vector comprising the nucleic acid molecule of claim 1 .
8. The vector of claim 7 wherein the vector is an expression vector.
9. A recombinant cell harboring the isolated nucleic acid molecule of claim 1 .
10. A recombinant cell harboring the vector of claim 7 .
11. The recombinant cell of claim 10 wherein the vector is an expression vector.